| Literature DB >> 16143521 |
Joseph Dudash1, Yongzheng Zhang, John B Moore, Richard Look, Yin Liang, Mary Pat Beavers, Bruce R Conway, Philip J Rybczynski, Keith T Demarest.
Abstract
A series of 3-anilino-quinoxalinones has been identified as a new class of glycogen phosphorylase inhibitors. The lead compound 1 was identified through high throughput screening as well as through pharmacophore-based electronic screening. Modifications were made to the scaffold of 1 to produce novel analogues, some of which are 25 times more potent than the lead compound.Entities:
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Year: 2005 PMID： 16143521 DOI： 10.1016/j.bmcl.2005.07.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823