BACKGROUND: The pathogenesis of interstitial lung disease remains under investigation, but may be related to increased inflammatory or cellular activity. This activity may be detectable with physiologic imaging. OBJECTIVES: We investigated the role of physiologic imaging using (18)F-2-fluoro-2-deoxy-D-glucose ((18)FDG)-positron emission tomography (PET) scans in idiopathic pulmonary fibrosis (IPF). METHODS: Seven male patients with histologically confirmed IPF underwent (18)FDG-PET scans. Scans were analyzed qualitatively and interpreted as positive or negative. Patients also underwent pulmonary function tests and computed tomography (CT) scans. RESULTS: The average total lung capacity was 71 +/- 22% predicted (mean +/- SD) and diffusing capacity for carbon monoxide was 44 +/- 14% predicted. All had changes consistent with IPF on chest CT and 2 patients had ground glass attenuation. Six of seven patients (86%) had a positive (18)FDG-PET scan. Changes in the (18)FDG-PET scan were seen in 1 patient corresponding to changes in clinical status. CONCLUSIONS: Our findings suggest that (18)FDG-PET scans may be helpful in the evaluation of IPF. Increased activity suggests active disease and changes in response to therapy.
BACKGROUND: The pathogenesis of interstitial lung disease remains under investigation, but may be related to increased inflammatory or cellular activity. This activity may be detectable with physiologic imaging. OBJECTIVES: We investigated the role of physiologic imaging using (18)F-2-fluoro-2-deoxy-D-glucose ((18)FDG)-positron emission tomography (PET) scans in idiopathic pulmonary fibrosis (IPF). METHODS: Seven male patients with histologically confirmed IPF underwent (18)FDG-PET scans. Scans were analyzed qualitatively and interpreted as positive or negative. Patients also underwent pulmonary function tests and computed tomography (CT) scans. RESULTS: The average total lung capacity was 71 +/- 22% predicted (mean +/- SD) and diffusing capacity for carbon monoxide was 44 +/- 14% predicted. All had changes consistent with IPF on chest CT and 2 patients had ground glass attenuation. Six of seven patients (86%) had a positive (18)FDG-PET scan. Changes in the (18)FDG-PET scan were seen in 1 patient corresponding to changes in clinical status. CONCLUSIONS: Our findings suggest that (18)FDG-PET scans may be helpful in the evaluation of IPF. Increased activity suggests active disease and changes in response to therapy.
Authors: Simone Cristina Soares Brandão; Júlia de Oliveira Xavier Ramos; Gustavo Freitas Alves de Arruda; Emmanuelle Tenório Albuquerque Madruga Godoi; Lara Cristiane Terra Ferreira Carreira; Rafael Willain Lopes; Gabriel Blacher Grossman; Ronaldo de Souza Leão Lima Journal: Am J Nucl Med Mol Imaging Date: 2020-12-15
Authors: Thida Win; Tryphon Lambrou; Brian F Hutton; Irfan Kayani; Nicholas J Screaton; Joanna C Porter; Toby M Maher; Raymondo Endozo; Robert I Shortman; Pauline Lukey; Ashley M Groves Journal: Eur J Nucl Med Mol Imaging Date: 2011-11-30 Impact factor: 9.236
Authors: Zachary T Rosenkrans; Christopher F Massey; Ksenija Bernau; Carolina A Ferreira; Justin J Jeffery; Jefree J Schulte; Melissa Moore; Frank Valla; Jeanine M Batterton; Christopher R Drake; Alan B McMillan; Nathan Sandbo; Ali Pirasteh; Reinier Hernandez Journal: Eur J Nucl Med Mol Imaging Date: 2022-05-12 Impact factor: 10.057
Authors: Thida Win; Benjamin A Thomas; Tryphon Lambrou; Brian F Hutton; Nicholas J Screaton; Joanna C Porter; Toby M Maher; Raymondo Endozo; Robert I Shortman; Asim Afaq; Pauline Lukey; Peter J Ell; Ashley M Groves Journal: Eur J Nucl Med Mol Imaging Date: 2013-08-14 Impact factor: 9.236