Literature DB >> 16141609

Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals.

Aiko Ebisawa1, Masahiro Hiratsuka, Kanako Sakuyama, Yumiko Konno, Takamitsu Sasaki, Michinao Mizugaki.   

Abstract

We analyzed all the exons and exon-intron junctions of the CYP2D6 gene from 286 Japanese individuals. We detected two novel single nucleotide polymorphisms (SNPs) 2556C>T in exon 5 (Thr261Ile) and 3835A>C in exon 8 (Lys404Gln). Both these SNPs showed a frequency of 0.002.

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Year:  2005        PMID： 16141609     DOI： 10.2133/dmpk.20.294

Source DB:  PubMed          Journal:  Drug Metab Pharmacokinet        ISSN： 1347-4367            Impact factor:   3.614


  4 in total

1.  Association of CYP2D6 polymorphisms and extrapyramidal symptoms in schizophrenia patients receiving risperidone: a retrospective study.

Authors:  Takahiro Ito; Kazuhiro Yamamoto; Fuminori Ohsawa; Ikuo Otsuka; Akitoyo Hishimoto; Ichiro Sora; Midori Hirai; Ikuko Yano
Journal:  J Pharm Health Care Sci       Date:  2018-11-19

2.  Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with attention-deficit/hyperactivity disorder.

Authors:  Takuya Saito; Yushiro Yamashita; Akemi Tomoda; Takashi Okada; Hideo Umeuchi; Saki Iwamori; Satoru Shinoda; Akiko Mizuno-Yasuhira; Hidetoshi Urano; Izumi Nishino; Kazuhiko Saito
Journal:  BMC Psychiatry       Date:  2020-11-10       Impact factor: 3.630

3.  The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping.

Authors:  Ya Feng Wen; Andrea Gaedigk; Erin C Boone; Wendy Y Wang; Robert J Straka
Journal:  Front Pharmacol       Date:  2022-03-21       Impact factor: 5.810

4.  The lowest effective plasma concentration of atomoxetine in pediatric patients with attention deficit/hyperactivity disorder: A non-randomized prospective interventional study.

Authors:  Atsunori Sugimoto; Yutaro Suzuki; Naoki Orime; Taketsugu Hayashi; Kiyohiro Yoshinaga; Jun Egawa; Shin Ono; Takuro Sugai; Yoshimasa Inoue; Toshiyuki Someya
Journal:  Medicine (Baltimore)       Date:  2021-07-09       Impact factor: 1.817
  4 in total

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