| Literature DB >> 16139170 |
Oliver Pogarell1, Gabriele Poepperl, Christoph Mulert, Christine Hamann, Nikolai Sadowsky, Michael Riedel, Hans-Juergen Moeller, Ulrich Hegerl, Klaus Tatsch.
Abstract
Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]beta-CIT and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.Entities:
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Year: 2005 PMID: 16139170 DOI: 10.1016/j.euroneuro.2005.01.003
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN: 0924-977X Impact factor: 4.600