| Literature DB >> 16139169 |
Magnus Schou1, Christer Halldin, Victor W Pike, P David Mozley, David Dobson, Robert B Innis, Lars Farde, Håkan Hall.
Abstract
The binding of the norepinephrine transporter radioligand, (S,S)-[18F]FMeNER-D2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus>>cortex approximately cerebellum approximately thalamus>caudate approximately putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram had no evident effect.Entities:
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Year: 2005 PMID： 16139169 DOI： 10.1016/j.euroneuro.2005.01.007
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN： 0924-977X Impact factor: 4.600