Literature DB >> 16137803

Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy.

Miguel Otero1, Sandra A Calarota, Anlan Dai, Anne S De Groot, Jean D Boyer, David B Weiner.   

Abstract

We tested a DNA vaccine strategy in order to improve the efficacy and safety of the current live smallpox vaccine involving priming with DNA vaccines and boosting with live vaccinia virus (VacV). We generated DNA plasmids encoding the A4L, A27L and H5R VacV genes. A considerable increase in antigen-specific IFN-gamma responses, high proliferative and humoral antigen-specific responses were detected in experimental primed Balb/C mice compared to controls after VacV boost. The VacV-DNA plasmids elicited IFN-gamma production in HLA-A2.1 transgenic mice in response to predicted HLA-A2.1 restricted peptide epitopes, providing valuable data for further vaccine development.

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Year:  2005        PMID： 16137803     DOI： 10.1016/j.vaccine.2005.08.010

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  12 in total

1.  Multivalent smallpox DNA vaccine delivered by intradermal electroporation drives protective immunity in nonhuman primates against lethal monkeypox challenge.

Authors:  Lauren A Hirao; Ruxandra Draghia-Akli; Jonathan T Prigge; Maria Yang; Abhishek Satishchandran; Ling Wu; Erika Hammarlund; Amir S Khan; Tahar Babas; Lowrey Rhodes; Peter Silvera; Mark Slifka; Niranjan Y Sardesai; David B Weiner
Journal:  J Infect Dis       Date:  2011-01-01       Impact factor: 5.226

2.  Coupling sensitive in vitro and in silico techniques to assess cross-reactive CD4(+) T cells against the swine-origin H1N1 influenza virus.

Authors:  Brian C Schanen; Anne S De Groot; L Moise; Matt Ardito; Elizabeth McClaine; William Martin; Vaughan Wittman; William L Warren; Donald R Drake
Journal:  Vaccine       Date:  2011-02-22       Impact factor: 3.641

3.  The identification of HLA class II-restricted T cell epitopes to vaccinia virus membrane proteins.

Authors:  Richard B Kennedy; Gregory A Poland
Journal:  Virology       Date:  2010-10-18       Impact factor: 3.616

4.  Human T-cell responses to vaccinia virus envelope proteins.

Authors:  Jie Tang; Mariam Murtadha; Matthias Schnell; Laurence C Eisenlohr; Jay Hooper; Phyllis Flomenberg
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

5.  Molecular smallpox vaccine delivered by alphavirus replicons elicits protective immunity in mice and non-human primates.

Authors:  Jay W Hooper; Anthony M Ferro; Joseph W Golden; Peter Silvera; Jeanne Dudek; Kim Alterson; Max Custer; Bryan Rivers; John Morris; Gary Owens; Jonathan F Smith; Kurt I Kamrud
Journal:  Vaccine       Date:  2009-10-13       Impact factor: 3.641

6.  Development of smallpox vaccine candidates with integrated interleukin-15 that demonstrate superior immunogenicity, efficacy, and safety in mice.

Authors:  Liyanage P Perera; Thomas A Waldmann; Joseph D Mosca; Nicole Baldwin; Jay A Berzofsky; SangKon Oh
Journal:  J Virol       Date:  2007-06-06       Impact factor: 5.103

7.  Genomic expression libraries for the identification of cross-reactive orthopoxvirus antigens.

Authors:  Lilija Miller; Marco Richter; Christoph Hapke; Daniel Stern; Andreas Nitsche
Journal:  PLoS One       Date:  2011-07-14       Impact factor: 3.240

8.  A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses.

Authors:  Ruicheng Wei; Chunfu Yang; Mei Zeng; Frances Terry; Kai Zhu; Chunhui Yang; Ralf Altmeyer; William Martin; Anne S De Groot; Qibin Leng
Journal:  PLoS One       Date:  2012-12-14       Impact factor: 3.240

Review 9.  Making vaccines "on demand": a potential solution for emerging pathogens and biodefense?

Authors:  Anne S De Groot; Leo Einck; Leonard Moise; Michael Chambers; John Ballantyne; Robert W Malone; Matthew Ardito; William Martin
Journal:  Hum Vaccin Immunother       Date:  2013-07-22       Impact factor: 3.452

10.  iVAX: An integrated toolkit for the selection and optimization of antigens and the design of epitope-driven vaccines.

Authors:  Leonard Moise; Andres Gutierrez; Farzana Kibria; Rebecca Martin; Ryan Tassone; Rui Liu; Frances Terry; Bill Martin; Anne S De Groot
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452
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