| Literature DB >> 16137794 |
Ziad Omran1, Thomas Cailly, Elodie Lescot, Jana Sopkova-de Oliveira Santos, Jean-Hugues Agondanou, Vincent Lisowski, Frédéric Fabis, Anne-Marie Godard, Silvia Stiebing, Guillaume Le Flem, Michel Boulouard, François Dauphin, Patrick Dallemagne, Sylvain Rault.
Abstract
Sixty-four new indanones and thiaindanones related to donepezil were synthesized and evaluated in vitro as potential AChE inhibitors. Among them, 11 derivatives were found to inhibit the enzyme in the submicromolar range; the best compound revealed its inhibitory activity with an IC50 in the same range (0.06 microM) than the reference compound, donepezil (IC50=0.02 microM).Entities:
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Year: 2005 PMID： 16137794 DOI： 10.1016/j.ejmech.2005.07.009
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514