Yan Zhu1, Zhao-Xia Xie. 1. Department of Hematology, Xiangya Hospital, Central South University, Changsha 41008, China.
Abstract
OBJECTIVE: To determine the relationship between nitric oxide synthase (NOS) expression and Pgp/mdr-1. METHODS: The expressions of iNOS, eNOS, and Pgp were detected by immunohistochemistry, and the expressions of iNOS gene and mdr-1 gene were detected by RT-PCR. RESULTS: NOS expression increased in patients with acute leukemia compared with that of the controls. There was some correlation between iNOS and Pgp/mdr-1 gene expression. CONCLUSION: NO may influcence multiple drug resistance in patients with acute leukemia.
OBJECTIVE: To determine the relationship between nitric oxide synthase (NOS) expression and Pgp/mdr-1. METHODS: The expressions of iNOS, eNOS, and Pgp were detected by immunohistochemistry, and the expressions of iNOS gene and mdr-1 gene were detected by RT-PCR. RESULTS: NOS expression increased in patients with acute leukemia compared with that of the controls. There was some correlation between iNOS and Pgp/mdr-1 gene expression. CONCLUSION: NO may influcence multiple drug resistance in patients with acute leukemia.
Authors: Soyeon Jeong; Bu Gyeom Kim; Dae Yeong Kim; Bo Ram Kim; Jung Lim Kim; Seong Hye Park; Yoo Jin Na; Min Jee Jo; Hye Kyeong Yun; Yoon A Jeong; Hong Jun Kim; Sun Il Lee; Han Do Kim; Dae Hyun Kim; Sang Cheul Oh; Dae-Hee Lee Journal: Cancers (Basel) Date: 2019-06-05 Impact factor: 6.639