BACKGROUND: Infection with intestinal helminths may stimulate dysfunctional immune responses in human immunodeficiency virus (HIV)-infected persons. Studies have yielded conflicting results regarding the impact of antihelminthic treatment on plasma concentrations of HIV-1 RNA.Methods. We conducted a prospective study of 54 HIV-1- and helminth-coinfected and 57 HIV-1-infected, helminth-uninfected asymptomatic adults living in Lusaka, Zambia, to assess the impact of antihelminthic treatment on plasma concentrations of HIV-1 RNA. RESULTS: Median baseline viral load was 0.33 log(10) copies/mL lower in the helminth-infected group than in the uninfected group. Mean viral load between pretreatment and posttreatment visits increased in the helminth-infected (mean, 4.23 vs. 4.29 log(10) copies/mL; P=.6) and helminth-uninfected (mean, 4.39 vs. 4.52 log(10) copies/mL; P=.2) groups. Helminth-infected participants with high pretreatment viral loads had a mean 0.25-log(10) copies/mL decrease after treatment (P=.3), and helminth-uninfected participants had a mean 0.02-log(10) copies/mL decrease (P=.8). CONCLUSIONS: We did not find an overall association between treatment of intestinal helminth infections and reduction in viral load in coinfected adults. Future studies may need to focus on adults with intense helminth infections who live in rural areas or on adults or children who harbor higher helminth burdens and plasma concentrations of HIV-1 RNA.
BACKGROUND: Infection with intestinal helminths may stimulate dysfunctional immune responses in human immunodeficiency virus (HIV)-infectedpersons. Studies have yielded conflicting results regarding the impact of antihelminthic treatment on plasma concentrations of HIV-1 RNA.Methods. We conducted a prospective study of 54 HIV-1- and helminth-coinfected and 57 HIV-1-infected, helminth-uninfected asymptomatic adults living in Lusaka, Zambia, to assess the impact of antihelminthic treatment on plasma concentrations of HIV-1 RNA. RESULTS: Median baseline viral load was 0.33 log(10) copies/mL lower in the helminth-infected group than in the uninfected group. Mean viral load between pretreatment and posttreatment visits increased in the helminth-infected (mean, 4.23 vs. 4.29 log(10) copies/mL; P=.6) and helminth-uninfected (mean, 4.39 vs. 4.52 log(10) copies/mL; P=.2) groups. Helminth-infectedparticipants with high pretreatment viral loads had a mean 0.25-log(10) copies/mL decrease after treatment (P=.3), and helminth-uninfected participants had a mean 0.02-log(10) copies/mL decrease (P=.8). CONCLUSIONS: We did not find an overall association between treatment of intestinal helminth infections and reduction in viral load in coinfected adults. Future studies may need to focus on adults with intense helminth infections who live in rural areas or on adults or children who harbor higher helminth burdens and plasma concentrations of HIV-1 RNA.
Authors: T Messele; M Abdulkadir; A L Fontanet; B Petros; D Hamann; M Koot; M T Roos; P T Schellekens; F Miedema; T F Rinke de Wit Journal: Clin Exp Immunol Date: 1999-03 Impact factor: 4.330
Authors: P E Palumbo; C Raskino; S Fiscus; S Pahwa; M G Fowler; S A Spector; J A Englund; C J Baker Journal: JAMA Date: 1998-03-11 Impact factor: 56.272
Authors: Michael Brown; Moses Kizza; Christine Watera; Maria A Quigley; Samantha Rowland; Peter Hughes; James A G Whitworth; Alison M Elliott Journal: J Infect Dis Date: 2004-10-20 Impact factor: 5.226
Authors: Laura R Sangaré; Bradley R Herrin; Bradely R Herrin; Grace John-Stewart; Judd L Walson Journal: Parasitology Date: 2011-05-18 Impact factor: 3.234
Authors: Jennifer A Downs; Govert J van Dam; John M Changalucha; Paul L A M Corstjens; Robert N Peck; Claudia J de Dood; Heejung Bang; Aura Andreasen; Samuel E Kalluvya; Lisette van Lieshout; Warren D Johnson; Daniel W Fitzgerald Journal: Am J Trop Med Hyg Date: 2012-10-01 Impact factor: 2.345
Authors: Judd L Walson; Phelgona A Otieno; Margaret Mbuchi; Barbra A Richardson; Barbara Lohman-Payne; Steve Wanyee Macharia; Julie Overbaugh; James Berkley; Eduard J Sanders; Michael H Chung; Grace C John-Stewart Journal: AIDS Date: 2008-08-20 Impact factor: 4.177
Authors: Patrick William Woodburn; Lawrence Muhangi; Stephen Hillier; Juliet Ndibazza; Proscovia Bazanya Namujju; Moses Kizza; Christine Ameke; Nicolas Emojong Omoding; Mark Booth; Alison Mary Elliott Journal: PLoS Negl Trop Dis Date: 2009-06-30
Authors: Mila Ayash-Rashkovsky; Agnès-Laurence Chenine; Lisa N Steele; Sandra J Lee; Ruijiang Song; Helena Ong; Robert A Rasmussen; Regina Hofmann-Lehmann; James G Else; Peter Augostini; Harold M McClure; W Evan Secor; Ruth M Ruprecht Journal: Infect Immun Date: 2007-02-05 Impact factor: 3.441
Authors: Kawsar R Talaat; Nagalingeswaran Kumarasamy; Soumya Swaminathan; Ramya Gopinath; Thomas B Nutman Journal: Am J Trop Med Hyg Date: 2008-10 Impact factor: 2.345