OBJECTIVE: The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia. METHOD: They used [18F]fluorodeoxyglucose positron emission tomography in 41 unmedicated patients with schizophrenia and 59 normal comparison subjects. RESULTS: A metabolic disconnection was observed in patients with schizophrenia in the left hemisphere between the mediodorsal nucleus and widespread frontotemporal cortical regions, and stronger-than-normal intercorrelations were found between the pulvinar and superior temporal, selected parietal, posterior cingulate, and occipital areas. CONCLUSIONS: Deficits in the functional interrelationships between the left frontotemporal cortices and the left mediodorsal nucleus of the thalamus complement inferences from postmortem and magnetic resonance imaging volumetric studies identifying a thalamic diathesis in schizophrenia.
OBJECTIVE: The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia. METHOD: They used [18F]fluorodeoxyglucose positron emission tomography in 41 unmedicated patients with schizophrenia and 59 normal comparison subjects. RESULTS: A metabolic disconnection was observed in patients with schizophrenia in the left hemisphere between the mediodorsal nucleus and widespread frontotemporal cortical regions, and stronger-than-normal intercorrelations were found between the pulvinar and superior temporal, selected parietal, posterior cingulate, and occipital areas. CONCLUSIONS: Deficits in the functional interrelationships between the left frontotemporal cortices and the left mediodorsal nucleus of the thalamus complement inferences from postmortem and magnetic resonance imaging volumetric studies identifying a thalamic diathesis in schizophrenia.
Authors: Serge A Mitelman; Marie-Cecile Bralet; M Mehmet Haznedar; Eric Hollander; Lina Shihabuddin; Erin A Hazlett; Monte S Buchsbaum Journal: Brain Imaging Behav Date: 2018-04 Impact factor: 3.978
Authors: Emily C Balevich; M Mehmet Haznedar; Eugene Wang; Randall E Newmark; Rachel Bloom; Jason S Schneiderman; Jonathan Aronowitz; Cheuk Y Tang; King-Wai Chu; William Byne; Monte S Buchsbaum; Erin A Hazlett Journal: Psychiatry Res Date: 2015-01-08 Impact factor: 3.222
Authors: Sebastien Parnaudeau; Pia-Kelsey O'Neill; Scott S Bolkan; Ryan D Ward; Atheir I Abbas; Bryan L Roth; Peter D Balsam; Joshua A Gordon; Christoph Kellendonk Journal: Neuron Date: 2013-03-20 Impact factor: 17.173
Authors: Johann Steiner; Aye Mu Myint; Kolja Schiltz; Sabine Westphal; Hans-Gert Bernstein; Martin Walter; Matthias L Schroeter; Markus J Schwarz; Bernhard Bogerts Journal: Cardiovasc Psychiatry Neurol Date: 2010-06-10