PURPOSE: Leptin, an adipocyte-derived cytokine that is elevated in obesity, has been associated with carcinogenesis, tumor migration and invasion, enhancement of angiogenesis, and increased aromatase activity. It has been suggested that leptin may mediate adverse prognostic effects of obesity in breast cancer. PATIENTS AND METHODS: Four hundred seventy-one women with surgically resected T1-3, N0-1, M0 breast cancer were studied. Leptin was assayed in stored fasting blood specimens obtained before adjuvant therapy. Women were followed prospectively for distant disease-free survival (DDFS) and overall survival (OS). RESULTS: Patients ranged from 26 to 74 years of age, and staging was as follows: T1 = 262, T2 = 151, T3 = 23, TX = 35, N0 = 323, and N1 = 148. Estrogen receptor was positive in 286 patients, and progesterone receptor was positive in 259 patients. One hundred forty-five patients received adjuvant chemotherapy, 146 received adjuvant tamoxifen, 46 received both, and 134 received neither. Mean leptin was 15.2 +/- 10.1 ng/mL. Univariately, leptin was associated with OS (overall P = .049; P = .014 postmenopausal). Leptin was not associated with DDFS overall or in any menopausal subgroup (P > or = .19). In multivariate Cox modeling, leptin was not significantly associated with DDFS or OS (P = .11 and 0.075, respectively). Adjustment for insulin or body mass index further reduced the association of leptin with outcome. CONCLUSION: Although leptin is strongly correlated with obesity and insulin, we could not show that it is independently associated with prognosis in early-stage breast cancer. Because we cannot rule out modest prognostic effects, we recommend additional research to explore this potential association, particularly in postmenopausal women.
PURPOSE: Leptin, an adipocyte-derived cytokine that is elevated in obesity, has been associated with carcinogenesis, tumor migration and invasion, enhancement of angiogenesis, and increased aromatase activity. It has been suggested that leptin may mediate adverse prognostic effects of obesity in breast cancer. PATIENTS AND METHODS: Four hundred seventy-one women with surgically resected T1-3, N0-1, M0 breast cancer were studied. Leptin was assayed in stored fasting blood specimens obtained before adjuvant therapy. Women were followed prospectively for distant disease-free survival (DDFS) and overall survival (OS). RESULTS:Patients ranged from 26 to 74 years of age, and staging was as follows: T1 = 262, T2 = 151, T3 = 23, TX = 35, N0 = 323, and N1 = 148. Estrogen receptor was positive in 286 patients, and progesterone receptor was positive in 259 patients. One hundred forty-five patients received adjuvant chemotherapy, 146 received adjuvant tamoxifen, 46 received both, and 134 received neither. Mean leptin was 15.2 +/- 10.1 ng/mL. Univariately, leptin was associated with OS (overall P = .049; P = .014 postmenopausal). Leptin was not associated with DDFS overall or in any menopausal subgroup (P > or = .19). In multivariate Cox modeling, leptin was not significantly associated with DDFS or OS (P = .11 and 0.075, respectively). Adjustment for insulin or body mass index further reduced the association of leptin with outcome. CONCLUSION: Although leptin is strongly correlated with obesity and insulin, we could not show that it is independently associated with prognosis in early-stage breast cancer. Because we cannot rule out modest prognostic effects, we recommend additional research to explore this potential association, particularly in postmenopausal women.
Authors: Antonio Macciò; Clelia Madeddu; Giulia Gramignano; Carlo Mulas; Carlo Floris; Daniela Massa; Giorgio Astara; Paola Chessa; Giovanni Mantovani Journal: J Mol Med (Berl) Date: 2010-03-26 Impact factor: 4.599
Authors: Gertraud Maskarinec; Ian Pagano; Galina Lurie; Erin Bantum; Carolyn C Gotay; Brian F Issell Journal: J Womens Health (Larchmt) Date: 2011-01-31 Impact factor: 2.681
Authors: Ludovic Zimmerlin; Albert D Donnenberg; J Peter Rubin; Per Basse; Rodney J Landreneau; Vera S Donnenberg Journal: Tissue Eng Part A Date: 2010-09-17 Impact factor: 3.845
Authors: A Goday; I Barneto; J M García-Almeida; A Blasco; A Lecube; C Grávalos; P Martínez de Icaya; R de las Peñas; S Monereo; L Vázquez; J E Palacio; P Pérez-Segura Journal: Clin Transl Oncol Date: 2015-06-03 Impact factor: 3.405
Authors: Ronald C Eldridge; Nicolas Wentzensen; Ruth M Pfeiffer; Louise A Brinton; Patricia Hartge; Chantal Guillemette; Troy J Kemp; Ligia A Pinto; Britton Trabert Journal: Cancer Causes Control Date: 2020-02-25 Impact factor: 2.506
Authors: Pamela J Goodwin; Wendy R Parulekar; Karen A Gelmon; Lois E Shepherd; Jennifer A Ligibel; Dawn L Hershman; Priya Rastogi; Ingrid A Mayer; Timothy J Hobday; Julie Lemieux; Alastair M Thompson; Kathleen I Pritchard; Timothy J Whelan; Som D Mukherjee; Haji I Chalchal; Conrad D Oja; Katia S Tonkin; Vanessa Bernstein; Bingshu E Chen; Vuk Stambolic Journal: J Natl Cancer Inst Date: 2015-03-04 Impact factor: 13.506
Authors: Marilyn L Kwan; Wendy Y Chen; Candyce H Kroenke; Erin K Weltzien; Jeannette M Beasley; Sarah J Nechuta; Elizabeth M Poole; Wei Lu; Michelle D Holmes; Charles P Quesenberry; John P Pierce; Xiao Ou Shu; Bette J Caan Journal: Breast Cancer Res Treat Date: 2011-12-21 Impact factor: 4.872
Authors: Pingping Xu; Weiping Ye; Saiyi Zhong; Robert Jen; Hong Li; Eric Feng; Shu-Hong Lin; Jie-Yu Liu; Young C Lin Journal: Oncol Lett Date: 2010-11-23 Impact factor: 2.967
Authors: Jennifer A Crozier; Alvaro Moreno-Aspitia; Karla V Ballman; Amylou C Dueck; Barbara A Pockaj; Edith A Perez Journal: Cancer Date: 2013-04-12 Impact factor: 6.860