Literature DB >> 16134260

Drug treatment of haemorrhoids.

Mahesh C Misra1.   

Abstract

Drug treatment for various anorectal conditions has been known since ancient times. Today, modern as well as traditional drugs are being increasingly used in all grades of symptomatic haemorrhoids. These drugs (oral and local) are used as a part of conservative management or as an adjuvant to invasive outpatient procedures. Flavonoids, in the new formulation of micronised purified flavonoid fraction (MPFF) or as part of the ancient traditional medicine derivative of the Ginkgo tree, are used for relief of acute symptoms (for control of bleeding and re-bleeding in all grades of haemorrhoids). MPFF has been recommended for control of acute bleeding in patients waiting for a definitive outpatient treatment. Similarly, better known drugs such as calcium dobisilate (used in diabetic retinopathy and chronic venous insufficiency), nitrates and nifedipine have also been effective and well tolerated in the medical treatment of haemorrhoids. However, drug treatment is not aimed at curing haemorrhoids. The prime objective of drug therapy is to control the acute phase (bleeding) so that definitive therapy (banding, injection sclerotherapy, infrared photocoagulation, cryotherapy or surgery) can be scheduled at a convenient time.

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Year:  2005        PMID: 16134260     DOI: 10.2165/00003495-200565110-00003

Source DB:  PubMed          Journal:  Drugs        ISSN: 0012-6667            Impact factor:   9.546


  43 in total

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Journal:  Dis Colon Rectum       Date:  2001-05       Impact factor: 4.585

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Authors:  Do Yeon Hwang; Seo-Gue Yoon; Hyun Shig Kim; Jong Kyun Lee; Kwang Yun Kim
Journal:  Dis Colon Rectum       Date:  2003-07       Impact factor: 4.585

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Journal:  Angiology       Date:  1994-06       Impact factor: 3.619

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Review 8.  Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders.

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Journal:  Drugs       Date:  1992-12       Impact factor: 9.546

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10.  [Effects of administration of 50 mg heparan sulfate tablets to patients with varicose dilatation of the hemorrhoid plexus (hemorrhoids)].

Authors:  L De Cecco
Journal:  Minerva Ginecol       Date:  1992-11
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  10 in total

1.  Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids: A randomized controlled trial.

Authors:  Francisco Hernández-Bernal; Georgina Castellanos-Sierra; Carmen M Valenzuela-Silva; Karem M Catasús-Álvarez; Osmany Martínez-Serrano; Odalys C Lazo-Diago; Cimara H Bermúdez-Badell; José R Causa-García; Juan E Domínguez-Suárez
Journal:  World J Gastroenterol       Date:  2015-06-21       Impact factor: 5.742

2.  Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial (THERESA-3).

Authors:  Francisco Hernández-Bernal; Georgina Castellanos-Sierra; Carmen M Valenzuela-Silva; Karem M Catasús-Álvarez; Roselin Valle-Cabrera; Ana Aguilera-Barreto; Pedro A López-Saura
Journal:  World J Gastroenterol       Date:  2014-02-14       Impact factor: 5.742

Review 3.  Treatment of hemorrhoids: A coloproctologist's view.

Authors:  Varut Lohsiriwat
Journal:  World J Gastroenterol       Date:  2015-08-21       Impact factor: 5.742

4.  Portuguese Society of Gastroenterology Consensus on the Diagnosis and Management of Hemorrhoidal Disease.

Authors:  Paulo Salgueiro; Ana Célia Caetano; Ana Maria Oliveira; Bruno Rosa; Miguel Mascarenhas-Saraiva; Paula Ministro; Pedro Amaro; Rogério Godinho; Rosa Coelho; Rúben Gaio; Samuel Fernandes; Vítor Fernandes; Fernando Castro-Poças
Journal:  GE Port J Gastroenterol       Date:  2019-09-05

5.  A randomized, double-blind, placebo-controlled trial of a Chinese herbal Sophora flower formula in patients with symptomatic haemorrhoids: a preliminary study.

Authors:  Kee-Ming Man; Wen-Chi Chen; Hwei-Ming Wang; Huey-Yi Chen; Jui-Lung Shen; Lieh-Der Chen; Fuu-Jen Tsai; Yung-Hsiang Chen; De-Xin Yu; Feng-Fan Chiang
Journal:  Afr J Tradit Complement Altern Med       Date:  2012-12-31

Review 6.  Hemorrhoids: from basic pathophysiology to clinical management.

Authors:  Varut Lohsiriwat
Journal:  World J Gastroenterol       Date:  2012-05-07       Impact factor: 5.742

Review 7.  Haemorrhoids: an update on management.

Authors:  Steven R Brown
Journal:  Ther Adv Chronic Dis       Date:  2017-06-21       Impact factor: 5.091

8.  Comparative metabolomic responses to gibberellic acid and 6-benzylaminopurine in Cunila menthoides Benth. (Lamiaceae): a contribution to understand the metabolic pathways.

Authors:  Joana P S Oliveira; Maria Gabriela B Koblitz; Mariana S L Ferreira; L C Cameron; Andrea F Macedo
Journal:  Plant Cell Rep       Date:  2018-05-23       Impact factor: 4.570

9.  Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents.

Authors:  Xiaofei Chen; Liang Guo; Qin Ma; Wei Chen; Wenxi Fan; Jie Zhang
Journal:  Molecules       Date:  2019-08-14       Impact factor: 4.411

10.  Micronized Purified Flavonoid Fraction in Hemorrhoid Disease: A Systematic Review and Meta-Analysis.

Authors:  Parvez Sheikh; Varut Lohsiriwat; Yury Shelygin
Journal:  Adv Ther       Date:  2020-05-12       Impact factor: 3.845

  10 in total

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