Literature DB >> 16134134

Long-term survival with non-proportional hazards: results from the Dutch Gastric Cancer Trial.

H Putter1, M Sasako, H H Hartgrink, C J H van de Velde, J C van Houwelingen.   

Abstract

Randomized clinical trials with long-term survival data comparing two treatments often show Kaplan-Meier plots with crossing survival curves. Such behaviour implies a violation of the proportional hazards assumption for treatment. The Cox proportional hazards regression model with treatment as a fixed effect can therefore not be used to assess the influence of treatment of survival. In this paper we analyse long-term follow-up data from the Dutch Gastric Cancer Trial, a randomized study comparing limited (D1) lymph node dissection with extended (D2) lymph node dissection. We illustrate a number of ways of dealing with survival data that do not obey the proportional hazards assumption, each of which can be easily implemented in standard statistical packages. Copyright 2005 John Wiley & Sons, Ltd.

Entities:  

Mesh：

Year:  2005        PMID： 16134134     DOI： 10.1002/sim.2143

Source DB:  PubMed          Journal:  Stat Med        ISSN： 0277-6715            Impact factor:   2.373


  11 in total

1.  Time-varying coefficients in a multivariate frailty model: Application to breast cancer recurrences of several types and death.

Authors:  Yassin Mazroui; Audrey Mauguen; Simone Mathoulin-Pélissier; Gaetan MacGrogan; Véronique Brouste; Virginie Rondeau
Journal:  Lifetime Data Anal       Date:  2015-05-06       Impact factor: 1.588

2.  Time-Varying Effects of Breast Cancer Adjuvant Systemic Therapy.

Authors:  Ismail Jatoi; Hanna Bandos; Jong-Hyeon Jeong; William F Anderson; Edward H Romond; Eleftherios P Mamounas; Norman Wolmark
Journal:  J Natl Cancer Inst       Date:  2015-10-30       Impact factor: 13.506

3.  Sequential tests for non-proportional hazards data.

Authors:  Matthias Brückner; Werner Brannath
Journal:  Lifetime Data Anal       Date:  2016-03-11       Impact factor: 1.588

4.  Bias-adjusted Kaplan-Meier survival curves for marginal treatment effect in observational studies.

Authors:  Xiaofei Wang; Fangfang Bai; Herbert Pang; Stephen L George
Journal:  J Biopharm Stat       Date:  2019-07-09       Impact factor: 1.051

5.  Variables with time-varying effects and the Cox model: some statistical concepts illustrated with a prognostic factor study in breast cancer.

Authors:  Carine A Bellera; Gaëtan MacGrogan; Marc Debled; Christine Tunon de Lara; Véronique Brouste; Simone Mathoulin-Pélissier
Journal:  BMC Med Res Methodol       Date:  2010-03-16       Impact factor: 4.615

Review 6.  Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells.

Authors:  Susanna Wl de Geus; Victor M Baart; Martin C Boonstra; Peter Jk Kuppen; Hendrica Ajm Prevoo; Andrew P Mazar; Bert A Bonsing; Hans Morreau; Cornelis Jh van de Velde; Alexander L Vahrmeijer; Cornelis Fm Sier
Journal:  Biomark Insights       Date:  2017-06-22

7.  Patients with coronary artery disease after acute myocardial infarction: effects of continuous enrollment in a structured Disease Management Program on adherence to guideline-recommended medication, health care expenditures, and survival.

Authors:  Florian Kirsch; Christian Becker; Anja Schramm; Werner Maier; Reiner Leidl
Journal:  Eur J Health Econ       Date:  2020-02-01

8.  Estimating restricted mean survival time and expected life-years lost in the presence of competing risks within flexible parametric survival models.

Authors:  Sarwar I Mozumder; Mark J Rutherford; Paul C Lambert
Journal:  BMC Med Res Methodol       Date:  2021-03-11       Impact factor: 4.615

9.  Patterns and predictors of first and subsequent recurrence in women with early breast cancer.

Authors:  Y M Geurts; A Witteveen; R Bretveld; P M Poortmans; G S Sonke; L J A Strobbe; S Siesling
Journal:  Breast Cancer Res Treat       Date:  2017-07-04       Impact factor: 4.872

10.  Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts.

Authors:  C S Thesing; A Lok; Y Milaneschi; J Assies; C L H Bockting; C A Figueroa; E J Giltay; B W J H Penninx; H G Ruhé; A H Schene; M Bot; R J T Mocking
Journal:  Acta Psychiatr Scand       Date:  2019-12-26       Impact factor: 6.392
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.