Literature DB >> 16133787

The DBH -1021 C/T polymorphism is not associated with alcoholism but possibly with patients' exposure to life events.

M T M V Freire1, M H Hutz, C H D Bau.   

Abstract

Two DBH polymorphisms were investigated in 114 Brazilian alcoholics of European descent and 233 controls. Personality and life events were also analyzed among alcoholics. No significant differences were observed in allele or genotype frequencies between alcoholics and controls. No association was detected between the polymorphisms and personality dimensions. Carriers of the -1021 T allele presented a higher number (F = 7.49; P = 0.007) of life events. This study provides a preliminary indication that the DBH -1021 C/T polymorphism influences the exposure to life events.

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Year:  2005        PMID： 16133787     DOI： 10.1007/s00702-005-0339-8

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  22 in total

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