Literature DB >> 1613300

Age-related alterations in the strength and collagen content of left colon in rats.

H Christensen1, T T Andreassen, H Oxlund.   

Abstract

The biomechanical properties and intestinal wall composition of left colon were studied in 4-month-old, 14-month-old, and 27-month-old male rats. The hydroxyproline content and hydroxyproline concentration in old rats were increased by 36% and 26%, respectively, compared with young rats and by 20% and 17%, respectively, compared with middle-aged rats. In middle-aged rats the maximum load increased by 21%, compared with young rats. In old rats, however, the maximum load decreased by 13%, compared with middle-aged rats. Histological examination showed that the mean crypt height was 9% higher in middle-aged rats and 12% higher in old rats than in young rats. In conclusion, an accumulation of collagenous proteins was found in old rats compared with middle-aged rats and this was accompanied by a decrease in the strength, which may deteriorate the functional integrity of the left colonic wall with age.

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Year:  1992        PMID： 1613300     DOI： 10.1007/bf00341292

Source DB:  PubMed          Journal:  Int J Colorectal Dis        ISSN： 0179-1958            Impact factor:   2.571


  10 in total

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Authors:  S G Webster; J T Leeming
Journal:  Age Ageing       Date:  1975-08       Impact factor: 10.668

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Authors:  H J Thomson; A Busuttil; M A Eastwood; A N Smith; R A Elton
Journal:  Int J Colorectal Dis       Date:  1987-11       Impact factor: 2.571

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Journal:  Gut       Date:  1969-05       Impact factor: 23.059

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Journal:  Gut       Date:  1985-04       Impact factor: 23.059

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Journal:  Connect Tissue Res       Date:  1982       Impact factor: 3.417

Review 9.  Diverticular disease--is it a motility disorder?

Authors:  M A Eastwood; D A Watters; A N Smith
Journal:  Clin Gastroenterol       Date:  1982-09

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Authors:  A N Smith; J Shepherd; M A Eastwood
Journal:  Gut       Date:  1981-10       Impact factor: 23.059
  10 in total
  5 in total

1.  Decrease in collagenous proteins and mechanical strength of distal colon after diverting colostomy in rats.

Authors:  P Kissmeyer-Nielsen; H Christensen; S Laurberg
Journal:  Int J Colorectal Dis       Date:  1993-09       Impact factor: 2.571

2.  Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity.

Authors:  Magnus S Ågren; Thomas L Andersen; Line Andersen; Christine Bruun Schiødt; Vikas Surve; Troels T Andreassen; Juha Risteli; Lennart E Franzén; Jean-Marie Delaissé; Anne-Marie Heegaard; Lars N Jorgensen
Journal:  Int J Colorectal Dis       Date:  2010-12-31       Impact factor: 2.571

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Journal:  PLoS One       Date:  2022-06-17       Impact factor: 3.752

4.  Effect of Source Animal Age upon Macrophage Response to Extracellular Matrix Biomaterials.

Authors:  Samuel T LoPresti; Bryan N Brown
Journal:  J Immunol Regen Med       Date:  2018-04-25

5.  Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies.

Authors:  Charlotte Gistelinck; Ronald Y Kwon; Fransiska Malfait; Sofie Symoens; Matthew P Harris; Katrin Henke; Michael B Hawkins; Shannon Fisher; Patrick Sips; Brecht Guillemyn; Jan Willem Bek; Petra Vermassen; Hanna De Saffel; Paul Eckhard Witten; MaryAnn Weis; Anne De Paepe; David R Eyre; Andy Willaert; Paul J Coucke
Journal:  Proc Natl Acad Sci U S A       Date:  2018-08-06       Impact factor: 11.205
  5 in total

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