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Literature DB >> 16132305

Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.

T C Slesnick¹, A R Mott, C D Fraser, A C Chang.

Abstract

We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia. The patient was readmitted with symptoms of rhinorrhea, poor feeding, and decreased activity level. She was found to have diffuse pulmonary infiltrates on chest radiograph and a marked peripheral eosinophilia without leukocytosis. After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.

Entities: Chemical

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Year: 2005 PMID： 16132305 DOI： 10.1007/s00246-004-0863-6

Source DB: PubMed Journal: Pediatr Cardiol ISSN： 0172-0643 Impact factor: 1.838

13 in total

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Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.

1. Pulmonary eosinophilia.

2. Cutaneous reaction to captopril with positive patch test and lack of cross-sensitivity to enalapril and benazepril.

3. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.

4. Chronic eosinophilic pneumonia.

5. Absence of cross-reactivity between captopril and enalapril.

Review 6. Drug-induced pulmonary disease. Part 2: Noncytotoxic drugs.

Review 7. Captopril-induced cough.

8. Captopril, an angiotensin-converting enzyme inhibitor, induced pulmonary infiltration with eosinophilia.

9. Captopril-induced hypersensitivity lung disease. An immune-complex-mediated phenomenon.

10. Prolonged nasal eosinophilia in allergic patients after common cold.

1. ACE inhibitors: upper respiratory symptoms.