Literature DB >> 16131423

Genetics of parkinsonism.

Alistair J Lewthwaite1, David J Nicholl.   

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Some debate still exists as to whether PD is predominantly environmental or genetic in etiology. The genetic hypothesis of PD etiology has been driven recently by the identification of a number of PD loci. This review deals with each of these loci, discussing the latest data and evidence available. Of particular interest are the recently described mutations in the PINK1 (PARK6) and LRRK2 (PARK8) genes. We also consider the impact of these latest developments on our understanding of sporadic PD and on our everyday practice with PD patients.

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Year:  2005        PMID： 16131423     DOI： 10.1007/s11910-005-0064-6

Source DB:  PubMed          Journal:  Curr Neurol Neurosci Rep        ISSN： 1528-4042            Impact factor:   5.081


  91 in total

1.  Autosomal dominant familial Parkinson disease: older onset of age, and good response to levodopa therapy.

Authors:  K Hasegawa; H Kowa
Journal:  Eur Neurol       Date:  1997       Impact factor: 1.710

2.  The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.

Authors:  Alexander Zimprich; Bertram Müller-Myhsok; Matthew Farrer; Petra Leitner; Manu Sharma; Mary Hulihan; Paul Lockhart; Audrey Strongosky; Jennifer Kachergus; Donald B Calne; Jon Stoessl; Ryan J Uitti; Ronald F Pfeiffer; Claudia Trenkwalder; Nikolaus Homann; Erwin Ott; Karoline Wenzel; Friedrich Asmus; John Hardy; Zbigniew Wszolek; Thomas Gasser
Journal:  Am J Hum Genet       Date:  2003-12-19       Impact factor: 11.025

3.  Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.

Authors:  H Shimura; N Hattori; S i Kubo; Y Mizuno; S Asakawa; S Minoshima; N Shimizu; K Iwai; T Chiba; K Tanaka; T Suzuki
Journal:  Nat Genet       Date:  2000-07       Impact factor: 38.330

4.  Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.

Authors:  P J Kahle; M Neumann; L Ozmen; V Muller; H Jacobsen; A Schindzielorz; M Okochi; U Leimer; H van Der Putten; A Probst; E Kremmer; H A Kretzschmar; C Haass
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

5.  Initiation and synergistic fibrillization of tau and alpha-synuclein.

Authors:  Benoit I Giasson; Mark S Forman; Makoto Higuchi; Lawrence I Golbe; Charles L Graves; Paul T Kotzbauer; John Q Trojanowski; Virginia M-Y Lee
Journal:  Science       Date:  2003-04-25       Impact factor: 47.728

Review 6.  Synucleinopathies: clinical and pathological implications.

Authors:  J E Galvin; V M Lee; J Q Trojanowski
Journal:  Arch Neurol       Date:  2001-02

7.  Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease.

Authors:  R Hering; S Petrovic; E-M Mietz; C Holzmann; D Berg; P Bauer; D Woitalla; T Müller; K Berger; R Krüger; O Riess
Journal:  Neurology       Date:  2004-04-13       Impact factor: 9.910

8.  Linkage disequilibrium and association of MAPT H1 in Parkinson disease.

Authors:  Lisa Skipper; Kristen Wilkes; Mathias Toft; Matthew Baker; Sarah Lincoln; Mary Hulihan; Owen A Ross; Mike Hutton; Jan Aasly; Matthew Farrer
Journal:  Am J Hum Genet       Date:  2004-08-03       Impact factor: 11.025

Review 9.  Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease.

Authors:  Vincenzo Bonifati; Ben A Oostra; Peter Heutink
Journal:  J Mol Med (Berl)       Date:  2004-01-08       Impact factor: 4.599

Review 10.  Parkin's substrates and the pathways leading to neuronal damage.

Authors:  Mark R Cookson
Journal:  Neuromolecular Med       Date:  2003       Impact factor: 4.103
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  5 in total

Review 1.  PARK8 LRRK2 parkinsonism.

Authors:  Kristoffer Haugarvoll; Zbigniew K Wszolek
Journal:  Curr Neurol Neurosci Rep       Date:  2006-07       Impact factor: 5.081

2.  Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.

Authors:  Wanli W Smith; Zhong Pei; Haibing Jiang; Darren J Moore; Yideng Liang; Andrew B West; Valina L Dawson; Ted M Dawson; Christopher A Ross
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-13       Impact factor: 11.205

Review 3.  Neurodegeneration and cell replacement.

Authors:  Brandi K Ormerod; Theo D Palmer; Maeve A Caldwell
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2008-01-12       Impact factor: 6.237

4.  Models for LRRK2-Linked Parkinsonism.

Authors:  Tianxia Li; Dejun Yang; Sarah Sushchky; Zhaohui Liu; Wanli W Smith
Journal:  Parkinsons Dis       Date:  2011-04-07

5.  Parkinsonism and tremor disorders. A clinical approach.

Authors:  Hani Ts Benamer
Journal:  Libyan J Med       Date:  2007-06-01       Impact factor: 1.657
  5 in total

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