Literature DB >> 16131320

Selenoprotein synthesis: a unique translational mechanism used by a diverse family of proteins.

Peter R Hoffmann1, Marla J Berry.   

Abstract

The purpose of this review is to provide an overview of the unique mechanism by which mammalian selenoprotein synthesis occurs. Selenoprotein synthesis requires translational recoding of the UGA codon from a stop signal to a selenocysteine insertion signal (SECIS). Dedicated factors directly involved in this translation process include specific secondary structure in the mRNA (SECIS), a unique tRNA (Sec-tRNA(Sec)), an RNA binding protein (SBP2), and a specialized elongation factor (EFsec). Regulation of this process is discussed along with physiologic and clinical issues regarding selenoprotein synthesis, including the side effects associated with statin drugs.

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Year:  2005        PMID： 16131320     DOI： 10.1089/thy.2005.15.769

Source DB:  PubMed          Journal:  Thyroid        ISSN： 1050-7256            Impact factor:   6.568


  19 in total

Review 1.  Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges.

Authors:  Donald L St Germain; Valerie Anne Galton; Arturo Hernandez
Journal:  Endocrinology       Date:  2009-01-29       Impact factor: 4.736

2.  Expressed protein ligation for metalloprotein design and engineering.

Authors:  Kevin M Clark; Wilfred A van der Donk; Yi Lu
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

Review 3.  Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.

Authors:  Balázs Gereben; Ann Marie Zavacki; Scott Ribich; Brian W Kim; Stephen A Huang; Warner S Simonides; Anikó Zeöld; Antonio C Bianco
Journal:  Endocr Rev       Date:  2008-09-24       Impact factor: 19.871

Review 4.  Tuning the engine: an introduction to resources on post-transcriptional regulation of gene expression.

Authors:  Erik Dassi; Alessandro Quattrone
Journal:  RNA Biol       Date:  2012-09-20       Impact factor: 4.652

5.  Association of selenoprotein p with Alzheimer's pathology in human cortex.

Authors:  Frederick P Bellinger; Qing-Ping He; Miyoko T Bellinger; Yanling Lin; Arjun V Raman; Lon R White; Marla J Berry
Journal:  J Alzheimers Dis       Date:  2008-11       Impact factor: 4.472

Review 6.  Selenoproteins and oxidative stress-induced inflammatory tumorigenesis in the gut.

Authors:  Caitlyn W Barrett; Sarah P Short; Christopher S Williams
Journal:  Cell Mol Life Sci       Date:  2016-08-25       Impact factor: 9.261

7.  Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia.

Authors:  S Talbot; R Nelson; W T Self
Journal:  Br J Pharmacol       Date:  2008-04-21       Impact factor: 8.739

Review 8.  The human selenoproteome: recent insights into functions and regulation.

Authors:  M A Reeves; P R Hoffmann
Journal:  Cell Mol Life Sci       Date:  2009-04-28       Impact factor: 9.261

9.  Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.

Authors:  Jodi L Bubenik; Andrea N Ladd; Carri A Gerber; Michael E Budiman; Donna M Driscoll
Journal:  RNA Biol       Date:  2009-01-05       Impact factor: 4.652

10.  A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3β aggravates acetaminophen-induced hepatic protein nitration.

Authors:  Jun-Won Yun; Krystal Lum; Xin Gen Lei
Journal:  Free Radic Biol Med       Date:  2013-06-26       Impact factor: 7.376
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