BACKGROUND: Data are scarce on liver involvement in adult patients with dengue virus infection. METHODS: During a recent outbreak of dengue fever in Uttar Pradesh, India, we looked for evidence of liver dysfunction among patients with dengue fever. RESULTS: A total of 45 patients with dengue fever (age 7-65 [median 33] years; 29 men; 39 adults) were studied, including 23 with uncomplicated dengue fever, 15 with dengue haemorrhagic fever and 7 with dengue shock syndrome. The median platelet count was 34 x 10(9)/L (9-99 x 10(9)). Seven patients (15%) had jaundice, 11 (24%) hepatomegaly and 9 clinically detectable ascites; none had splenomegaly. Twelve patients (30%) had hyperbilirubinaemia. Serum alanine and aspartate aminotransferase activities were elevated in 43 patients (96%) each; 5-fold elevated levels were more frequent in severe disease. Hypoalbuminaemia was found in 31/41 patients (76%). Seven patients died, including 2 with acute liver failure. CONCLUSION: Our data show that liver injury is common in adult patients with dengue infection. Further studies are needed to determine the mechanism of liver injury in this disease.
BACKGROUND: Data are scarce on liver involvement in adult patients with dengue virus infection. METHODS: During a recent outbreak of dengue fever in Uttar Pradesh, India, we looked for evidence of liver dysfunction among patients with dengue fever. RESULTS: A total of 45 patients with dengue fever (age 7-65 [median 33] years; 29 men; 39 adults) were studied, including 23 with uncomplicated dengue fever, 15 with dengue haemorrhagic fever and 7 with dengue shock syndrome. The median platelet count was 34 x 10(9)/L (9-99 x 10(9)). Seven patients (15%) had jaundice, 11 (24%) hepatomegaly and 9 clinically detectable ascites; none had splenomegaly. Twelve patients (30%) had hyperbilirubinaemia. Serum alanine and aspartate aminotransferase activities were elevated in 43 patients (96%) each; 5-fold elevated levels were more frequent in severe disease. Hypoalbuminaemia was found in 31/41 patients (76%). Seven patients died, including 2 with acute liver failure. CONCLUSION: Our data show that liver injury is common in adult patients with dengue infection. Further studies are needed to determine the mechanism of liver injury in this disease.
Authors: Nieli Rodrigues da Costa Faria; Victor Edgar Fiestas Solorzano; Luiz José de Souza; Rita Maria Ribeiro Nogueira; Fernanda de Bruycker-Nogueira; Thaís Chouin-Carneiro; Jaqueline Bastos Santos Simões; Monique da Rocha Queiroz Lima; Luzia Maria de Oliveira Pinto; Claire Fernandes Kubelka; Manoela Heringer; Elzinandes Leal de Azeredo; Flavia Barreto Dos Santos Journal: Am J Trop Med Hyg Date: 2017-07 Impact factor: 2.345
Authors: Belisa M L Magalhães; Márcia A A Alexandre; André M Siqueira; Gisely C Melo; João B L Gimaque; Michele S Bastos; Regina M P Figueiredo; Ricardo C Carvalho; Michel A Tavares; Felipe G Naveca; Pedro Alonso; Quique Bassat; Marcus V G Lacerda; Maria P G Mourão Journal: Am J Trop Med Hyg Date: 2012-10-01 Impact factor: 2.345
Authors: Nikos Vasilakis; Eleanor R Deardorff; Joan L Kenney; Shannan L Rossi; Kathryn A Hanley; Scott C Weaver Journal: PLoS Pathog Date: 2009-06-05 Impact factor: 6.823