| Literature DB >> 16130491 |
C Luís1, E G Cothran, M M Oom, E Bailey.
Abstract
The major histocompatibility complex (MHC) genes play well-defined roles in eliciting immune responses and combating infectious diseases. This genetic system is among the most polymorphic. The extent of genetic variation within a population has been directly correlated with fitness for many traits. The MHC class II locus DRA polymorphism was analysed in the endangered Sorraia horse, two other Portuguese and four New World horse breeds considered to be historically close to the Sorraia. Comparison of the Sorraia with other breeds demonstrated less MHC variation among Sorraia horses. If DRA polymorphism provides greater disease resistance, selective breeding to increase MHC polymorphism may increase fitness of this population.Entities:
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Year: 2005 PMID： 16130491 DOI： 10.1111/j.1439-0388.2004.00485.x
Source DB: PubMed Journal: J Anim Breed Genet ISSN： 0931-2668 Impact factor: 2.380