Zuzana Gdovinová1. 1. Department of Neurology, Faculty of Medicine, P.J. Safárik University Kosice, Tr. SNP 1, 040 66 Kosice, Slovak Republic. gdovin@central.medic.upjs.sk
Abstract
OBJECTIVE: The aim of the study was to measure changes in blood flow velocity (V(mean)) and erythrocyte deformability (ED) in heavy alcohol drinkers after withdrawal and the relationship between them. METHODS: The subjects were 32 heavy alcohol drinkers, mean age 47 years (22 men and 10 women). V(mean) was determined by a transcranial 2 MHz pulsed Doppler probe. ED was estimated by the method of cation-osmotic haemolysis (COH). The results were compared with those for 20 healthy volunteers. RESULTS: The study revealed a significant decrease in V(mean) and ED after admission. V(mean) in the left middle cerebral artery (MCA) was 45.1+/-10.2 cm/s as compared with 59.1+/-7.5 cm/s in controls; in the right MCA, it was 46.8+/-11.3 cm/s as compared with 59.0+/-7.6 cm/s in controls (p < 0.001 in each case). But while V(mean) was significantly increased after 14 days withdrawal (54.4+/-10.4 cm/s in the left MCA, p < 0.001, and 54.3+/-12.1 cm/s in the right MCA, p < 0.01), ED showed only small change. A significant difference between V(mean) in men and women was found. CONCLUSION: The changes in V(mean) after withdrawal are more influenced by plasma composition than by changes in ED.
OBJECTIVE: The aim of the study was to measure changes in blood flow velocity (V(mean)) and erythrocyte deformability (ED) in heavy alcohol drinkers after withdrawal and the relationship between them. METHODS: The subjects were 32 heavy alcohol drinkers, mean age 47 years (22 men and 10 women). V(mean) was determined by a transcranial 2 MHz pulsed Doppler probe. ED was estimated by the method of cation-osmotic haemolysis (COH). The results were compared with those for 20 healthy volunteers. RESULTS: The study revealed a significant decrease in V(mean) and ED after admission. V(mean) in the left middle cerebral artery (MCA) was 45.1+/-10.2 cm/s as compared with 59.1+/-7.5 cm/s in controls; in the right MCA, it was 46.8+/-11.3 cm/s as compared with 59.0+/-7.6 cm/s in controls (p < 0.001 in each case). But while V(mean) was significantly increased after 14 days withdrawal (54.4+/-10.4 cm/s in the left MCA, p < 0.001, and 54.3+/-12.1 cm/s in the right MCA, p < 0.01), ED showed only small change. A significant difference between V(mean) in men and women was found. CONCLUSION: The changes in V(mean) after withdrawal are more influenced by plasma composition than by changes in ED.