| Literature DB >> 16129554 |
Ashwin A Dihal1, Ruud A Woutersen, Ben van Ommen, Ivonne M C M Rietjens, Rob H Stierum.
Abstract
The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001<P<0.05). During differentiation Caco-2 cells formed 5 phase II metabolites, of which the amount of 4'-O-methyl-quercetin-3'-O-glucuronide correlated with the differentiation grade (r=0.99, P<0.003). The increment of cell proliferation at low quercetin concentrations and the decrease in cell differentiation are effects opposite to what would be expected for a functional food ingredient with anti-carcinogenic potential.Entities:
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Year: 2005 PMID： 16129554 DOI： 10.1016/j.canlet.2005.07.007
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679