Literature DB >> 16129447

A screening assay for detecting CD8+ cell non-cytotoxic anti-HIV responses.

M Scott Killian1, Sharon Ng, Carl E Mackewicz, Jay A Levy.   

Abstract

The rate of HIV-1 disease progression is influenced by several factors that include pathogen and host genetic variations and the quality of antiviral immune responses. The CD8+ cell non-cytotoxic antiviral response (CNAR) substantially suppresses HIV replication in CD4+ cells and is positively associated with an asymptomatic clinical state. Traditionally, the measurement of CNAR has required several culture procedures and costly reagents. Here we report the development and validation of a screening assay for detection of CNAR that accurately identifies individuals benefiting from this response. Use of the CNAR screening assay should facilitate the evaluation of this important immune parameter in studies of HIV pathogenesis, resistance to infection, and vaccine development.

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Year:  2005        PMID： 16129447     DOI： 10.1016/j.jim.2005.07.016

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  7 in total

1.  Recovery and assessment of leukocytes from LR Express filters.

Authors:  Abby K Wegehaupt; Ellen K Roufs; Cory R Hewitt; Marisela L Killian; Oxana Gorbatenko; Cynthia M Anderson; M Scott Killian
Journal:  Biologicals       Date:  2017-07-31       Impact factor: 1.856

Review 2.  The CD8+ T Cell Noncytotoxic Antiviral Responses.

Authors:  Maelig G Morvan; Fernando C Teque; Christopher P Locher; Jay A Levy
Journal:  Microbiol Mol Biol Rev       Date:  2021-05-12       Impact factor: 11.056

3.  Analysis of the CD8+ T cell anti-HIV activity in heterologous cell co-cultures reveals the benefit of multiple HLA class I matches.

Authors:  M Scott Killian; Fernando Teque; Ramu Sudhagoni
Journal:  Immunogenetics       Date:  2017-07-22       Impact factor: 2.846

4.  Natural suppression of human immunodeficiency virus type 1 replication is mediated by transitional memory CD8+ T cells.

Authors:  M Scott Killian; Carl Johnson; Fernando Teque; Sue Fujimura; Jay A Levy
Journal:  J Virol       Date:  2010-12-08       Impact factor: 5.103

5.  Autologous CD4/CD8 co-culture assay: a physiologically-relevant composite measure of CD8+ T lymphocyte function in HIV-infected persons.

Authors:  Steven R Fauce; Otto O Yang; Rita B Effros
Journal:  J Immunol Methods       Date:  2007-08-08       Impact factor: 2.303

6.  CD8(+) lymphocytes suppress human immunodeficiency virus 1 replication by secreting type I interferons.

Authors:  M Scott Killian; Fernando Teque; Robert L Walker; Paul S Meltzer; J Keith Killian
Journal:  J Interferon Cytokine Res       Date:  2013-02-12       Impact factor: 2.607

7.  Nevirapine inhibits the anti-HIV activity of CD8+ cells.

Authors:  Lianxing Liu; Lin Wang; Liusheng Huang; Vincent Siu; Fernando Teque; Francesca T Aweeka; Jay A Levy
Journal:  J Acquir Immune Defic Syndr       Date:  2013-06-01       Impact factor: 3.731
  7 in total

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