BACKGROUND: Recently, the 5-lipoxygenase activating protein gene (ALOX5AP) was reported to confer a risk of myocardial infarction (MI) and stroke, independent of conventional risk factors. The purpose of the present study was to validate those findings in a Japanese population. METHODS AND RESULTS: The study population consisted of 1,875 subjects (males 871, females 1,004) recruited from the Suita study (control group) and 353 subjects (males 306, females 47) with MI. The promoter, all of the exons, and 3'UTR regions of ALOX5AP were sequenced in 96 subjects, and 8 polymorphisms were found. There were significant differences in the frequencies of the haplotypes constructed from the 2 SNPs (A162C and T8733A) between the control and MI groups. Multiple logistic analysis indicated that the homozygous genotype of the (CA) haplotype was significantly associated with a reduced risk for MI. CONCLUSION: The hypothesis that ALOX5AP contributes to susceptibility for MI was validated in a Japanese population.
BACKGROUND: Recently, the 5-lipoxygenase activating protein gene (ALOX5AP) was reported to confer a risk of myocardial infarction (MI) and stroke, independent of conventional risk factors. The purpose of the present study was to validate those findings in a Japanese population. METHODS AND RESULTS: The study population consisted of 1,875 subjects (males 871, females 1,004) recruited from the Suita study (control group) and 353 subjects (males 306, females 47) with MI. The promoter, all of the exons, and 3'UTR regions of ALOX5AP were sequenced in 96 subjects, and 8 polymorphisms were found. There were significant differences in the frequencies of the haplotypes constructed from the 2 SNPs (A162C and T8733A) between the control and MI groups. Multiple logistic analysis indicated that the homozygous genotype of the (CA) haplotype was significantly associated with a reduced risk for MI. CONCLUSION: The hypothesis that ALOX5AP contributes to susceptibility for MI was validated in a Japanese population.
Authors: Kathryn J Moore; Simon Koplev; Edward A Fisher; Ira Tabas; Johan L M Björkegren; Amanda C Doran; Jason C Kovacic Journal: J Am Coll Cardiol Date: 2018-10-30 Impact factor: 24.094
Authors: Ahmad Alwan; Sonia C Youhanna; Daniel E Platt; Mirvat El-Sibai; Joumana S Yerezian; Mary E Deeb; Georges Khazen; Stephanie Saadé; Tony G Zreik; Hamid El Bayeh; Assaad Maalouf; Antoine Abchee; Pierre A Zalloua Journal: J Community Genet Date: 2010-08-18
Authors: Jinying Zhao; Mary J Roman; Richard B Devereux; Fawn Yeh; Ying Zhang; Karin Haack; Lyle G Best; Shelley A Cole; Elisa T Lee; Barbara V Howard Journal: Atherosclerosis Date: 2014-01-10 Impact factor: 5.162
Authors: Nicholas B Larson; Paul A Decker; Christina L Wassel; James S Pankow; Weihong Tang; Naomi Q Hanson; Michael Y Tsai; Suzette J Bielinski Journal: Hum Genet Date: 2016-02-16 Impact factor: 4.132