Literature DB >> 16126395

Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents.

Anu Agarwal1, Neena Goyal, Prem M S Chauhan, Suman Gupta.   

Abstract

A series of dihydropyrido[2,3-d]pyrimidines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 2a-2l have shown 83-100% inhibition against promastigotes and 79-100% inhibition against amastigotes at a concentration of 50 microg/mL.

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Year:  2005        PMID： 16126395     DOI： 10.1016/j.bmc.2005.07.043

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Synthesis of a new series of substituted pyrimidines and its evaluation for antibacterial and antinociceptive effects.

Authors:  Akhlaq Waheed; Mohammad S Alorainy; Abdullah A Alghasham; Suroor A Khan; Muhammad Raza
Journal:  Int J Health Sci (Qassim)       Date:  2008-01

2.  Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea.

Authors:  Alexander Y Kots; Byung-Kwon Choi; Maria E Estrella-Jimenez; Cirle A Warren; Scott R Gilbertson; Richard L Guerrant; Ferid Murad
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-16       Impact factor: 11.205

3.  Design, Synthesis, and In Vitro Antimicrobial Evaluation of Fused Pyrano[3,2-e]tetrazolo[1,5-c]pyrimidines and Diazepines.

Authors:  Sankari Kanakaraju; P Sagar Vijay Kumar; Bethanamudi Prasanna; G V P Chandramouli
Journal:  ISRN Org Chem       Date:  2013-08-21

4.  Synthesis and cytotoxic evaluation of some novel 3-[2-(2-phenyl-thiazol-4-yl)-ethyl]-3H-pyrido[2,3-d]pyrimidin-4-one derivatives.

Authors:  Marzieh Rahmani Khajouei; Ghadamali Khodarahmi; Aram Ghaderi
Journal:  Res Pharm Sci       Date:  2021-08-19

5.  Microwave assisted one-pot catalyst free green synthesis of new methyl-7-amino-4-oxo-5-phenyl-2-thioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carboxylates as potent in vitro antibacterial and antifungal activity.

Authors:  Ajmal R Bhat; Aabid H Shalla; Rajendra S Dongre
Journal:  J Adv Res       Date:  2014-11-01       Impact factor: 10.479

6.  Synthesis, Antitumor Evaluation and Molecular Docking of New Morpholine Based Heterocycles.

Authors:  Zeinab A Muhammad; Mastoura M Edrees; Rasha A M Faty; Sobhi M Gomha; Seham S Alterary; Yahia N Mabkhot
Journal:  Molecules       Date:  2017-07-20       Impact factor: 4.411
  6 in total

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