BACKGROUND: Smell identification deficits (SID) are common in adult schizophrenia, where they are associated with negative symptoms and lower intelligence. However, smell identification has not been examined in adolescents with early onset psychosis, wherein diagnosis is often obscure, and there are few prognostic predictors. METHOD: We examined smell identification, diagnosis, neuropsychological performance and symptoms in 26 well characterized adolescents with early onset psychosis, age 11-17 years. RESULTS: SID existed in the sample and were more common in patients with schizophrenia and psychotic depression than in patients with psychosis NOS and bipolar disorder. As in adults, SID were significantly associated with greater negative symptoms and lower verbal IQ. However, the associations of verbal IQ (and other verbal tasks) to smell identification in this pediatric sample were explained by the relation of both of these types of variables to negative symptoms. CONCLUSIONS: SID existed across this sample of youths with psychotic disorder, and were specifically related to typical characteristics of schizophrenia, such as negative symptoms and lower intelligence, but not to features of bipolar disorder, such as grandiosity. SID is a characteristic of early onset psychosis that may be useful for prognostic purposes.
BACKGROUND: Smell identification deficits (SID) are common in adult schizophrenia, where they are associated with negative symptoms and lower intelligence. However, smell identification has not been examined in adolescents with early onset psychosis, wherein diagnosis is often obscure, and there are few prognostic predictors. METHOD: We examined smell identification, diagnosis, neuropsychological performance and symptoms in 26 well characterized adolescents with early onset psychosis, age 11-17 years. RESULTS:SID existed in the sample and were more common in patients with schizophrenia and psychotic depression than in patients with psychosis NOS and bipolar disorder. As in adults, SID were significantly associated with greater negative symptoms and lower verbal IQ. However, the associations of verbal IQ (and other verbal tasks) to smell identification in this pediatric sample were explained by the relation of both of these types of variables to negative symptoms. CONCLUSIONS:SID existed across this sample of youths with psychotic disorder, and were specifically related to typical characteristics of schizophrenia, such as negative symptoms and lower intelligence, but not to features of bipolar disorder, such as grandiosity. SID is a characteristic of early onset psychosis that may be useful for prognostic purposes.
Authors: Eliza Coleman; Raymond R Goetz; David Leitman; Scott Yale; Ariel Stanford; Jack M Gorman; Dolores Malaspina Journal: CNS Spectr Date: 2002-01 Impact factor: 3.790
Authors: Vidyulata Kamath; Bruce I Turetsky; Monica E Calkins; Christian G Kohler; Catherine G Conroy; Karin Borgmann-Winter; Dana E Gatto; Raquel E Gur; Paul J Moberg Journal: World J Biol Psychiatry Date: 2011-11-10 Impact factor: 4.132
Authors: Kelly Elizabeth Gill; Elizabeth Evans; Jürgen Kayser; Shelly Ben-David; Julie Messinger; Gerard Bruder; Dolores Malaspina; Cheryl Mary Corcoran Journal: Psychiatry Res Date: 2014-07-17 Impact factor: 3.222
Authors: Martin Schecklmann; Christina Schwenck; Regina Taurines; Christine Freitag; Andreas Warnke; Manfred Gerlach; Marcel Romanos Journal: J Neural Transm (Vienna) Date: 2012-07-19 Impact factor: 3.575
Authors: Mary R Lee; Heidi J Wehring; Robert P McMahon; Jared Linthicum; Nicola Cascella; Fang Liu; Alan Bellack; Robert W Buchanan; Gregory P Strauss; Carlo Contoreggi; Deanna L Kelly Journal: Schizophr Res Date: 2013-02-13 Impact factor: 4.939
Authors: Jürgen Kayser; Craig E Tenke; Christopher J Kroppmann; Daniel M Alschuler; Shelly Ben-David; Shiva Fekri; Gerard E Bruder; Cheryl M Corcoran Journal: Int J Psychophysiol Date: 2013-07-13 Impact factor: 2.997