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Literature DB >> 16125141

Transcriptional signaling from membrane raft-associated glucocorticoid receptor.

Sudhir Jain¹, Yanna Li, Ashok Kumar, Pravin B Sehgal.

Abstract

The contribution of plasma membrane-associated glucocorticoid receptor (GR) to transcriptional signaling is unclear. We observed GR in low-density detergent-resistant membrane (DRM) rafts derived from human hepatoma Hep3B cells in complexes with caveolin-1, HSP90, and STAT3. In transient transfection assays, GR-stimulated transcriptional signaling was reversibly inhibited by membrane-raft disrupters filipin III and progesterone. These data provide clear evidence for a functional contribution of DRM-associated GR to transcriptional signaling.

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Year: 2005 PMID： 16125141 DOI： 10.1016/j.bbrc.2005.08.057

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

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Journal: J Neuroendocrinol Date: 2010-03-27 Impact factor: 3.627

2. Lipid raft- and protein kinase C-mediated synergism between glucocorticoid- and gonadotropin-releasing hormone signaling results in decreased cell proliferation.

Authors: Lancelot Wehmeyer; Andrea Du Toit; Dirk M Lang; Janet P Hapgood
Journal: J Biol Chem Date: 2014-02-19 Impact factor: 5.157

8. A novel non genomic glucocorticoid signaling mediated by a membrane palmitoylated glucocorticoid receptor cross talks with GnRH in gonadotrope cells.

Authors: Mohsen Ayrout; Violaine Simon; Valérie Bernard; Nadine Binart; Joëlle Cohen-Tannoudji; Marc Lombès; Stéphanie Chauvin
Journal: Sci Rep Date: 2017-05-08 Impact factor: 4.379

8 in total

Transcriptional signaling from membrane raft-associated glucocorticoid receptor.

Review 1. Nongenomic actions of adrenal steroids in the central nervous system.

2. Lipid raft- and protein kinase C-mediated synergism between glucocorticoid- and gonadotropin-releasing hormone signaling results in decreased cell proliferation.

Review 3. Paradigm shifts in the cell biology of STAT signaling.

4. Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid effects.

5. Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program.

Review 6. Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy.

7. Do the interactions between glucocorticoids and sex hormones regulate the development of the metabolic syndrome?

8. A novel non genomic glucocorticoid signaling mediated by a membrane palmitoylated glucocorticoid receptor cross talks with GnRH in gonadotrope cells.