Literature DB >> 16124763

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis.

Giovanni Appendino1, Simona Prosperini, Carola Valdivia, Mauro Ballero, Giampiero Colombano, Richard A Billington, Armando A Genazzani, Olov Sterner.   

Abstract

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

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Year:  2005        PMID： 16124763     DOI： 10.1021/np050115m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

Review 1.  Targeting thapsigargin towards tumors.

Authors:  Nhu Thi Quynh Doan; Eleonora Sandholdt Paulsen; Pankaj Sehgal; Jesper Vuust Møller; Poul Nissen; Samuel R Denmeade; John T Isaacs; Craig A Dionne; Søren Brøgger Christensen
Journal:  Steroids       Date:  2014-07-24       Impact factor: 2.668

2.  Discovery of novel SERCA inhibitors by virtual screening of a large compound library.

Authors:  Christopher Elam; Michael Lape; Joel Deye; Jodie Zultowsky; David T Stanton; Stefan Paula
Journal:  Eur J Med Chem       Date:  2011-02-25       Impact factor: 6.514

3.  From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development.

Authors:  Søren Brøgger Christensen; Henrik Toft Simonsen; Nikolai Engedal; Poul Nissen; Jesper Vuust Møller; Samuel R Denmeade; John T Isaacs
Journal:  Prog Chem Org Nat Prod       Date:  2021

Review 4.  Natural products as modulators of eukaryotic protein secretion.

Authors:  Hendrik Luesch; Ville O Paavilainen
Journal:  Nat Prod Rep       Date:  2020-02-18       Impact factor: 13.423

5.  Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase.

Authors:  Stefan Paula; Josh Abell; Joel Deye; Christopher Elam; Michael Lape; Justin Purnell; Robert Ratliff; Kelly Sebastian; Jodie Zultowsky; Robert J Kempton
Journal:  Bioorg Med Chem       Date:  2009-08-04       Impact factor: 3.641

6.  Total syntheses of (-)-transtaganolide A, (+)-transtaganolide B, (+)-transtaganolide C, and (-)-transtaganolide D and biosynthetic implications.

Authors:  Hosea M Nelson; Jonny R Gordon; Scott C Virgil; Brian M Stoltz
Journal:  Angew Chem Int Ed Engl       Date:  2013-05-16       Impact factor: 15.336

7.  Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus.

Authors:  Giovanni Appendino; Federica Pollastro; Luisella Verotta; Mauro Ballero; Adriana Romano; Paulina Wyrembek; Katarzyna Szczuraszek; Jerzy W Mozrzymas; Orazio Taglialatela-Scafati
Journal:  J Nat Prod       Date:  2009-05-22       Impact factor: 4.050

8.  New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

Authors:  Bolin Hou; Sushi Liu; Ruiyun Huo; Yueqian Li; Jinwei Ren; Wenzhao Wang; Tao Wei; Xuejun Jiang; Wenbing Yin; Hongwei Liu; Ling Liu; Erwei Li
Journal:  Mar Drugs       Date:  2021-06-24       Impact factor: 5.118
  8 in total

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