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Literature DB >> 1612462

Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity.

Abstract

Drosophila melanogaster flies climb up the sides of their vial after having been submitted to a mechanical stimulation; that ability is impaired at older ages. The climbing activity (CLI) of flies kept at various gravity levels (1, 3 and 5 g) has been measured throughout life, in cross-sectional studies. Hypergravity had no effect on CLI at young age, but older flies kept in hypergravity displayed lower scores than flies kept at 1 g. Results are discussed in relation with the hypothesis of increased aging rate in hypergravity.

Entities: Species

Mesh：

Year: 1992 PMID： 1612462 DOI： 10.1159/000213307

Source DB: PubMed Journal: Gerontology ISSN： 0304-324X Impact factor: 5.140

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Cited

29 in total

1. Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.

Authors: Guang-Ho Cha; Sunhong Kim; Jeehye Park; Eunji Lee; Myungjin Kim; Sung Bae Lee; Jin Man Kim; Jongkyeong Chung; Kyoung Sang Cho
Journal: Proc Natl Acad Sci U S A Date: 2005-07-07 Impact factor: 11.205

2. Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.

Authors: Patricia S Estes; Ashley Boehringer; Rebecca Zwick; Jonathan E Tang; Brianna Grigsby; Daniela C Zarnescu
Journal: Hum Mol Genet Date: 2011-03-26 Impact factor: 6.150

3. A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila.

Authors: J Sanchez-Garcia; K Jensen; Y Zhang; D E Rincon-Limas; P Fernandez-Funez
Journal: Neurobiol Dis Date: 2016-07-28 Impact factor: 5.996

4. Sequence-dependent prion protein misfolding and neurotoxicity.

Authors: Pedro Fernandez-Funez; Yan Zhang; Sergio Casas-Tinto; Xiangzhu Xiao; Wen-Quan Zou; Diego E Rincon-Limas
Journal: J Biol Chem Date: 2010-09-03 Impact factor: 5.157

5. Diphenyl Diselenide Protects Against Mortality, Locomotor Deficits and Oxidative Stress in Drosophila melanogaster Model of Manganese-Induced Neurotoxicity.

Authors: Isaac A Adedara; Amos O Abolaji; Joao B T Rocha; Ebenezer O Farombi
Journal: Neurochem Res Date: 2016-02-15 Impact factor: 3.996

6. Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.

Authors: Sheng Zhang; Mel B Feany; Sudipta Saraswati; J Troy Littleton; Norbert Perrimon
Journal: Dis Model Mech Date: 2009-04-06 Impact factor: 5.758

Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity.

1. Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.

2. Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.

3. A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila.

4. Sequence-dependent prion protein misfolding and neurotoxicity.

5. Diphenyl Diselenide Protects Against Mortality, Locomotor Deficits and Oxidative Stress in Drosophila melanogaster Model of Manganese-Induced Neurotoxicity.

6. Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.

7. Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.

8. Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.

9. D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals.

10. In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms.