Literature DB >> 16124409

A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae).

D T Huong1, D V Luong, T T P Thao, T V Sung.   

Abstract

A new flavone named miliufavol [8-(2-hydroxybenzyl)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one or 8-C-(o)-hydroxybenzylpachypodol] from Miliusa balansae (Annonaceae) was isolated and structurally elucidated by spectroscopic means besides four known flavones: ombuine, chrysosplenol B, pachypodol and chrysosplenol C. These flavonoids exhibited interesting cytotoxic activity against three human cell lines (KB, Hep-G2, RD) with IC50 values < 5 microg/ml.

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Year:  2005        PMID: 16124409

Source DB:  PubMed          Journal:  Pharmazie        ISSN: 0031-7144            Impact factor:   1.267


  7 in total

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2.  Chemical Diversity and Biological Activity of African Propolis.

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Journal:  Prog Chem Org Nat Prod       Date:  2019

Review 3.  Traditional Uses, Phytochemistry and Pharmacological Activities of Annonacae.

Authors:  Bassam S M Al Kazman; Joanna E Harnett; Jane R Hanrahan
Journal:  Molecules       Date:  2022-05-27       Impact factor: 4.927

4.  New neolignans and a phenylpropanoid glycoside from twigs of Miliusa mollis.

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Journal:  Molecules       Date:  2010-01-28       Impact factor: 4.411

5.  Pachypodol, a Methoxyflavonoid Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation.

Authors:  Eun Kyung Kim; Ji Hoon Kim; Soyeon Jeong; Yong Won Choi; Hyun Jung Choi; Chul Young Kim; Young-Mi Kim
Journal:  Int J Mol Sci       Date:  2019-08-21       Impact factor: 5.923

Review 6.  Genus Miliusa: A Review of Phytochemistry and Pharmacology.

Authors:  Ninh The Son
Journal:  Evid Based Complement Alternat Med       Date:  2019-08-14       Impact factor: 2.629

7.  Chemical Constituents With Antiproliferative Activity From Pogostemon cablin (Blanco) Benth.

Authors:  Xingjia Peng; Song Ang; Yizi Zhang; Fenling Fan; Mengshuo Wu; Peiting Liang; Yan Wen; Lishe Gan; Kun Zhang; Dongli Li; Jianmin Yue
Journal:  Front Chem       Date:  2022-07-15       Impact factor: 5.545

  7 in total

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