AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples. METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, beta-catenin, p53, CD44, MSH-2, MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups. RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear beta-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and clinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples. CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear beta-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data on in vivo human tumors.
AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples. METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, beta-catenin, p53, CD44, MSH-2, MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups. RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear beta-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and clinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples. CONCLUSION:AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear beta-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data on in vivo humantumors.
Authors: P Tangkijvanich; N Anukulkarnkusol; P Suwangool; S Lertmaharit; O Hanvivatvong; P Kullavanijaya; Y Poovorawan Journal: J Clin Gastroenterol Date: 2000-12 Impact factor: 3.062
Authors: Diego F Calvisi; Valentina M Factor; Sara Ladu; Elizabeth A Conner; Snorri S Thorgeirsson Journal: Gastroenterology Date: 2004-05 Impact factor: 22.682
Authors: M-A Forget; S Turcotte; D Beauseigle; J Godin-Ethier; S Pelletier; J Martin; S Tanguay; R Lapointe Journal: Br J Cancer Date: 2007-01-23 Impact factor: 7.640
Authors: Anna Georgina Kopasz; Dávid Zsolt Pusztai; Réka Karkas; Liza Hudoba; Khaldoon Sadiq Ahmed Abdullah; Gergely Imre; Gabriella Pankotai-Bodó; Ede Migh; Andrea Nagy; András Kriston; Péter Germán; Andrea Bakné Drubi; Anna Molnár; Ildikó Fekete; Virág Éva Dani; Imre Ocsovszki; László Géza Puskás; Péter Horváth; Farkas Sükösd; Lajos Mátés Journal: BMC Biol Date: 2022-04-01 Impact factor: 7.431