AIM: To investigate clinical significance of Pin1 and beta-catenin expression in colorectal cancers and to demonstrate the relationship of their expression. METHODS: The role of Pin1 and beta-catenin protein in colorectal tumorigenesis and their clinicopathologic significance were analyzed by immunohistochemistry, and the correlation between Pin1 and beta-catenin protein expressions was also studied in 124 patients with colorectal cancer who were surgically treated. RESULTS: Normal colonic epithelium either failed to express or showed focal and weak expression of Pin1 and beta-catenin. Overexpression of Pin1 and beta-catenin protein was found in 23 (18.54%) and 50 (40.3%) of 124 colorectal cancers, respectively. Overexpression of both proteins was not related to the lymph node metastasis, tumor stage and survival period after excision. Survival analysis results indicated that tumor stage was a valuable predictor of survival. Interestingly, a significant correlation was found between Pin1 and beta-catenin protein expression. CONCLUSION: Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of beta-catenin.
AIM: To investigate clinical significance of Pin1 and beta-catenin expression in colorectal cancers and to demonstrate the relationship of their expression. METHODS: The role of Pin1 and beta-catenin protein in colorectal tumorigenesis and their clinicopathologic significance were analyzed by immunohistochemistry, and the correlation between Pin1 and beta-catenin protein expressions was also studied in 124 patients with colorectal cancer who were surgically treated. RESULTS: Normal colonic epithelium either failed to express or showed focal and weak expression of Pin1 and beta-catenin. Overexpression of Pin1 and beta-catenin protein was found in 23 (18.54%) and 50 (40.3%) of 124 colorectal cancers, respectively. Overexpression of both proteins was not related to the lymph node metastasis, tumor stage and survival period after excision. Survival analysis results indicated that tumor stage was a valuable predictor of survival. Interestingly, a significant correlation was found between Pin1 and beta-catenin protein expression. CONCLUSION: Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of beta-catenin.
Authors: Roberta Pang; John Yuen; Man Fung Yuen; Ching Lung Lai; Terence K W Lee; Kwan Man; Ronnie T P Poon; Sheung Tat Fan; Chun M Wong; Irene O L Ng; Yok Lam Kwong; Eric Tse Journal: Oncogene Date: 2004-05-20 Impact factor: 9.867
Authors: Gustavo Ayala; Dagong Wang; Gerburg Wulf; Anna Frolov; Rile Li; Janusz Sowadski; Thomas M Wheeler; Kun Ping Lu; Lere Bao Journal: Cancer Res Date: 2003-10-01 Impact factor: 12.701
Authors: Kazuhiro Nakamura; Isao Kosugi; Daniel Y Lee; Angela Hafner; David A Sinclair; Akihide Ryo; Kun Ping Lu Journal: Mol Cell Biol Date: 2012-05-29 Impact factor: 4.272
Authors: Darya V Urusova; Jung-Hyun Shim; Dong Joon Kim; Sung Keun Jung; Tatyana A Zykova; Andria Carper; Ann M Bode; Zigang Dong Journal: Cancer Prev Res (Phila) Date: 2011-07-12
Authors: Yan Zhang; Sebastian Daum; Dirk Wildemann; Xiao Zhen Zhou; Mark A Verdecia; Marianne E Bowman; Christian Lücke; Tony Hunter; Kun-Ping Lu; Gunter Fischer; Joseph P Noel Journal: ACS Chem Biol Date: 2007-05-22 Impact factor: 5.100