Literature DB >> 16123536

Recombinant pharmaceuticals from plants: the plant endomembrane system as bioreactor.

Alessandro Vitale1, Emanuela Pedrazzini.   

Abstract

The production of safe pharmaceuticals at affordable costs is one of the great challenges of our times. Research has proven that transgenic plants can fulfill this need. This review focuses on the peculiar features of plant cells that allow high accumulation of recombinant proteins. The endomembrane system and the secretory pathway of plant cells in themselves offer a fascinating model of protein sorting, and in practical terms, represent the potential for the facile and very low-cost purification of recombinant pharmaceutical proteins.

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Year:  2005        PMID： 16123536     DOI： 10.1124/mi.5.4.5

Source DB:  PubMed          Journal:  Mol Interv        ISSN： 1534-0384


  29 in total

1.  Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds.

Authors:  Bart Van Droogenbroeck; Jingyuan Cao; Johannes Stadlmann; Friedrich Altmann; Sarah Colanesi; Stefan Hillmer; David G Robinson; Els Van Lerberge; Nancy Terryn; Marc Van Montagu; Mifang Liang; Ann Depicker; Geert De Jaeger
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-16       Impact factor: 11.205

Review 2.  SNAREs: cogs and coordinators in signaling and development.

Authors:  Diane C Bassham; Michael R Blatt
Journal:  Plant Physiol       Date:  2008-08       Impact factor: 8.340

3.  Plant derived veterinary vaccines.

Authors:  L Santi
Journal:  Vet Res Commun       Date:  2009-09       Impact factor: 2.459

4.  Validating the location of fluorescent protein fusions in the endomembrane system.

Authors:  Ian Moore; Angus Murphy
Journal:  Plant Cell       Date:  2009-06-26       Impact factor: 11.277

5.  Engineering and expression of a RhoA peptide against respiratory syncytial virus infection in plants.

Authors:  Benita Ortega-Berlanga; Konstantin Musiychuk; Yoko Shoji; Jessica A Chichester; Vidadi Yusibov; Omar Patiño-Rodríguez; Daniel E Noyola; Ángel G Alpuche-Solís
Journal:  Planta       Date:  2015-10-16       Impact factor: 4.116

Review 6.  The effect of the unfolded protein response on the production of recombinant proteins in plants.

Authors:  David Rhys Thomas; Amanda Maree Walmsley
Journal:  Plant Cell Rep       Date:  2014-09-04       Impact factor: 4.570

7.  Tobacco as biofactory for biologically active hPL production: a human hormone with potential applications in type-1 diabetes.

Authors:  Iratxe Urreta; Iñigo Oyanguren; Sonia Castañón
Journal:  Transgenic Res       Date:  2010-10-20       Impact factor: 2.788

8.  Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice.

Authors:  Huafang Lai; Michael Engle; Anja Fuchs; Thomas Keller; Syd Johnson; Sergey Gorlatov; Michael S Diamond; Qiang Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-01       Impact factor: 11.205

9.  Higher accumulation of F1-V fusion recombinant protein in plants after induction of protein body formation.

Authors:  M Lucrecia Alvarez; Emel Topal; Federico Martin; Guy A Cardineau
Journal:  Plant Mol Biol       Date:  2009-09-30       Impact factor: 4.076

10.  High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system.

Authors:  Zhong Huang; Waranyoo Phoolcharoen; Huafang Lai; Khanrat Piensook; Guy Cardineau; Larry Zeitlin; Kevin J Whaley; Charles J Arntzen; Hugh S Mason; Qiang Chen
Journal:  Biotechnol Bioeng       Date:  2010-05-01       Impact factor: 4.530
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