Literature DB >> 16123124

Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.

Adam C Resnick1, Adele M Snowman, Bingnan N Kang, K Joseph Hurt, Solomon H Snyder, Adolfo Saiardi.   

Abstract

Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhibited phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.

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Year:  2005        PMID： 16123124      PMCID： PMC1200306          DOI： 10.1073/pnas.0506184102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

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Journal:  Science       Date:  1999-07-02       Impact factor: 47.728

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Review 4.  Inositol trisphosphate and calcium signalling.

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Journal:  Nature       Date:  1993-01-28       Impact factor: 49.962

5.  A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae.

Authors:  A Baudin; O Ozier-Kalogeropoulos; A Denouel; F Lacroute; C Cullin
Journal:  Nucleic Acids Res       Date:  1993-07-11       Impact factor: 16.971

6.  Pleiotropic function of ArgRIIIp (Arg82p), one of the regulators of arginine metabolism in Saccharomyces cerevisiae. Role in expression of cell-type-specific genes.

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Journal:  Mol Gen Genet       Date:  1994-05-10

7.  Purification and characterization of phosphoinositide 3-kinase from rat liver.

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Journal:  J Biol Chem       Date:  1990-11-15       Impact factor: 5.157

8.  Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei.

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Journal:  Biochem J       Date:  1997-10-15       Impact factor: 3.857

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Authors:  Gregory J Miller; James H Hurley
Journal:  Mol Cell       Date:  2004-09-10       Impact factor: 17.970

10.  Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds.

Authors:  D Mumberg; R Müller; M Funk
Journal:  Gene       Date:  1995-04-14       Impact factor: 3.688
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  55 in total

1.  Mechanism of substrate specificity of phosphatidylinositol phosphate kinases.

Authors:  Yagmur Muftuoglu; Yi Xue; Xiang Gao; Dianqing Wu; Ya Ha
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-20       Impact factor: 11.205

Review 2.  Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate.

Authors:  Karsten Sauer; Michael P Cooke
Journal:  Nat Rev Immunol       Date:  2010-04       Impact factor: 53.106

3.  Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.

Authors:  Seyun Kim; Sangwon F Kim; David Maag; Micah J Maxwell; Adam C Resnick; Krishna R Juluri; Anutosh Chakraborty; Michael A Koldobskiy; Seung Hun Cha; Roxanne Barrow; Adele M Snowman; Solomon H Snyder
Journal:  Cell Metab       Date:  2011-02-02       Impact factor: 27.287

Review 4.  Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.

Authors:  Andrew M Seeds; Joshua P Frederick; Marco M K Tsui; John D York
Journal:  Adv Enzyme Regul       Date:  2007-01-05

Review 5.  Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes.

Authors:  Raymond D Blind
Journal:  Adv Biol Regul       Date:  2013-10-18

6.  Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways.

Authors:  A Chakraborty; C Latapy; J Xu; S H Snyder; J-M Beaulieu
Journal:  Mol Psychiatry       Date:  2013-02-26       Impact factor: 15.992

7.  Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.

Authors:  David Maag; Micah J Maxwell; Douglas A Hardesty; Katie L Boucher; Namrata Choudhari; Adam G Hanno; Jenny F Ma; Adele S Snowman; Joseph W Pietropaoli; Risheng Xu; Phillip B Storm; Adolfo Saiardi; Solomon H Snyder; Adam C Resnick
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-10       Impact factor: 11.205

Review 8.  Control of mammalian gene expression by selective mRNA export.

Authors:  Vihandha O Wickramasinghe; Ronald A Laskey
Journal:  Nat Rev Mol Cell Biol       Date:  2015-06-17       Impact factor: 94.444

9.  Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

Authors:  Chenglai Fu; Richa Tyagi; Alfred C Chin; Tomas Rojas; Ruo-Jing Li; Prasun Guha; Isaac A Bernstein; Feng Rao; Risheng Xu; Jiyoung Y Cha; Jing Xu; Adele M Snowman; Gregg L Semenza; Solomon H Snyder
Journal:  Circ Res       Date:  2017-12-26       Impact factor: 17.367

10.  Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction.

Authors:  Risheng Xu; Bindu D Paul; Dani R Smith; Richa Tyagi; Feng Rao; A Basit Khan; Daniel J Blech; M Scott Vandiver; Maged M Harraz; Prasun Guha; Ishrat Ahmed; Nilkantha Sen; Michela Gallagher; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205
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