Literature DB >> 16122704

Regulation of 5-lipoxygenase enzyme activity.

Olof Rådmark1, Bengt Samuelsson.   

Abstract

In this article, regulation of human 5-lipoxygenase enzyme activity is reviewed. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide. Also, studies on phosphorylation of 5-lipoxygenase and nuclear localization sequences are reviewed.

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Year:  2005        PMID： 16122704     DOI： 10.1016/j.bbrc.2005.08.013

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Expression, purification and crystallization of human 5-lipoxygenase-activating protein with leukotriene-biosynthesis inhibitors.

Authors:  Shihua Xu; Brian M McKeever; Douglas Wisniewski; Douglas K Miller; Robert H Spencer; Lin Chu; Feroze Ujjainwalla; Ting Ting Yamin; Jilly F Evans; Joseph W Becker; Andrew D Ferguson
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2007-11-30

2.  Expression of 5-lipoxygenase in specialized epithelial cells of nasopharyngeal-associated lymphoid tissue.

Authors:  Thomas G Brock
Journal:  J Mol Histol       Date:  2006-04-28       Impact factor: 2.611

3.  Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively.

Authors:  Ziying Jiang; Xinmin Yin; Qing Jiang
Journal:  J Immunol       Date:  2010-12-17       Impact factor: 5.422

4.  Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.

Authors:  Marija Rakonjac; Lutz Fischer; Patrick Provost; Oliver Werz; Dieter Steinhilber; Bengt Samuelsson; Olof Rådmark
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-21       Impact factor: 11.205

5.  MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.

Authors:  Bishuang Cai; Edward B Thorp; Amanda C Doran; Manikandan Subramanian; Brian E Sansbury; Chyuan-Sheng Lin; Matthew Spite; Gabrielle Fredman; Ira Tabas
Journal:  Proc Natl Acad Sci U S A       Date:  2016-05-19       Impact factor: 11.205

6.  5-Lipoxygenase: mechanisms of regulation.

Authors:  Olof Rådmark; Bengt Samuelsson
Journal:  J Lipid Res       Date:  2008-11-05       Impact factor: 5.922

7.  Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

Authors:  Christian Feisst; Carlo Pergola; Marija Rakonjac; Antonietta Rossi; Andreas Koeberle; Gabriele Dodt; Marika Hoffmann; Christina Hoernig; Lutz Fischer; Dieter Steinhilber; Lutz Franke; Gisbert Schneider; Olof Rådmark; Lidia Sautebin; Oliver Werz
Journal:  Cell Mol Life Sci       Date:  2009-07-05       Impact factor: 9.261

8.  Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach.

Authors:  Tatiana A Karelina; Kirill V Zhudenkov; Oleg O Demin; Dmitry V Svetlichny; Balaji Agoram; David Fairman; Oleg V Demin
Journal:  BMC Syst Biol       Date:  2012-11-12

9.  Chronic hypoxia promotes pulmonary artery endothelial cell proliferation through H2O2-induced 5-lipoxygenase.

Authors:  Kristi M Porter; Bum-Yong Kang; Sherry E Adesina; Tamara C Murphy; C Michael Hart; Roy L Sutliff
Journal:  PLoS One       Date:  2014-06-06       Impact factor: 3.240

10.  ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid.

Authors:  Christopher J Smyrniotis; Shannon R Barbour; Zexin Xia; Mark S Hixon; Theodore R Holman
Journal:  Biochemistry       Date:  2014-07-02       Impact factor: 3.162
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