Stephan Ihrler1, John D Harrison. 1. Pathologisches Institut, Ludwig Maximilians Universität, Munich, Germany. stephan.ihrler@patho.med.uni-muenchen.de
Abstract
OBJECTIVE: To remove the confusion surrounding the terms "Mikulicz's disease" and "Mikulicz's syndrome" by discovering the nature of the disease that Mikulicz described. STUDY DESIGN: Investigation of the original 1892 publication by Mikulicz in the light of current knowledge. RESULTS: Mikulicz described bilateral painless swellings of the lacrymal, major salivary, and minor salivary glands that were present for 14 months without a reduction in salivary flow before the patient, a man of 42 years, died. A print of a microscopical field of one of the submandibular glands contains a uniform lymphocytic infiltrate of centrocyte-like cells typical of MALT lymphoma, which is strongly supported by the reported clinical features. CONCLUSION: Mikulicz published the first case report of a MALT lymphoma of salivary glands, and the terms "Mikulicz's disease" and "Mikulicz's syndrome" should no longer be used.
OBJECTIVE: To remove the confusion surrounding the terms "Mikulicz's disease" and "Mikulicz's syndrome" by discovering the nature of the disease that Mikulicz described. STUDY DESIGN: Investigation of the original 1892 publication by Mikulicz in the light of current knowledge. RESULTS: Mikulicz described bilateral painless swellings of the lacrymal, major salivary, and minor salivary glands that were present for 14 months without a reduction in salivary flow before the patient, a man of 42 years, died. A print of a microscopical field of one of the submandibular glands contains a uniform lymphocytic infiltrate of centrocyte-like cells typical of MALT lymphoma, which is strongly supported by the reported clinical features. CONCLUSION: Mikulicz published the first case report of a MALT lymphoma of salivary glands, and the terms "Mikulicz's disease" and "Mikulicz's syndrome" should no longer be used.
Authors: John H Stone; Arezou Khosroshahi; Vikram Deshpande; John K C Chan; J Godfrey Heathcote; Rob Aalberse; Atsushi Azumi; Donald B Bloch; William R Brugge; Mollie N Carruthers; Wah Cheuk; Lynn Cornell; Carlos Fernandez-Del Castillo; Judith A Ferry; David Forcione; Günter Klöppel; Daniel L Hamilos; Terumi Kamisawa; Satomi Kasashima; Shigeyuki Kawa; Mitsuhiro Kawano; Yasufumi Masaki; Kenji Notohara; Kazuichi Okazaki; Ji Kon Ryu; Takako Saeki; Dushyant Sahani; Yasuharu Sato; Thomas Smyrk; James R Stone; Masayuki Takahira; Hisanori Umehara; George Webster; Motohisa Yamamoto; Eunhee Yi; Tadashi Yoshino; Giuseppe Zamboni; Yoh Zen; Suresh Chari Journal: Arthritis Rheum Date: 2012-10
Authors: Alan N Baer; Christine G Gourin; William H Westra; Darren P Cox; John S Greenspan; Troy E Daniels Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2012-11-10