Literature DB >> 16120430

Mitochondrial dysfunction in cancer.

Josephine S Modica-Napolitano1, Keshav K Singh.   

Abstract

Nearly a century of scientific research has revealed a number of notable differences in the structure and function of mitochondria between normal and cancer cells, including differences in metabolic activity, molecular composition, and mtDNA sequence. This article reviews several of these differences and discusses their clinical implications, especially with regard to the use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents.

Entities:  

Year:  2004        PMID： 16120430     DOI： 10.1016/j.mito.2004.07.027

Source DB:  PubMed          Journal:  Mitochondrion        ISSN： 1567-7249            Impact factor:   4.160


  102 in total

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Review 6.  Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer.

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Journal:  Mitochondrion       Date:  2005-06       Impact factor: 4.160

7.  Two-photon autofluorescence dynamics imaging reveals sensitivity of intracellular NADH concentration and conformation to cell physiology at the single-cell level.

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Journal:  J Photochem Photobiol B       Date:  2008-12-25       Impact factor: 6.252

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Authors:  Raquel Palao-Suay; María Rosa Aguilar; Francisco J Parra-Ruiz; Sergio Martín-Saldaña; Nathan A Rohner; Susan N Thomas; Julio San Román
Journal:  J Mater Sci Mater Med       Date:  2017-08-31       Impact factor: 3.896

9.  A novel role for mitochondria in regulating epigenetic modification in the nucleus.

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Journal:  Cancer Biol Ther       Date:  2008-08-01       Impact factor: 4.742

10.  Mitochondria single nucleotide variation across six blood cell types.

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Journal:  Mitochondrion       Date:  2016-03-05       Impact factor: 4.160
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