Literature DB >> 16120313

The human complex I NDUFS4 subunit: from gene structure to function and pathology.

S M S Budde1, L P W J van den Heuvel, J A M Smeitink.   

Abstract

Complex I is the first and largest enzyme of the oxidative phosphorylation system. It consists of at least 43 subunits. Recent studies have shown that the NDUFS4 subunit of complex I contributes to the activation of the complex through cAMP dependent phosphorylation of a conserved site (RVS) located at the C-terminal region of this protein. This report focuses on the NDUFS4 subunit. Summarized is the current knowledge of this subunit, from gene structure to function and pathology.

Entities:  

Year:  2002        PMID： 16120313     DOI： 10.1016/s1567-7249(02)00035-1

Source DB:  PubMed          Journal:  Mitochondrion        ISSN： 1567-7249            Impact factor:   4.160


  6 in total

1.  Clusterin increases mitochondrial respiratory chain complex I activity and protects against hexavalent chromium-induced cytotoxicity in L-02 hepatocytes.

Authors:  Yuanyuan Xiao; Ming Zeng; Lirong Yin; Na Li; Fang Xiao
Journal:  Toxicol Res (Camb)       Date:  2018-11-15       Impact factor: 3.524

2.  Molecular characterization and expression analysis of NDUFS4 gene in m. longissimus dorsi of Laiwu pig (Sus scrofa).

Authors:  Qimei Chen; Yongqing Zeng; Hui Wang; Lun Yang; Yun Yang; Honglei Zhu; Yuan Shi; Wei Chen; Yanxia Hu
Journal:  Mol Biol Rep       Date:  2012-10-18       Impact factor: 2.316

Review 3.  Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency.

Authors:  Saskia Koene; Peter H G M Willems; Peggy Roestenberg; Werner J H Koopman; Jan A M Smeitink
Journal:  J Inherit Metab Dis       Date:  2010-01-27       Impact factor: 4.982

4.  cAMP/PKA Signaling Modulates Mitochondrial Supercomplex Organization.

Authors:  Anna Signorile; Consiglia Pacelli; Luigi Leonardo Palese; Arcangela Santeramo; Emilio Roca; Tiziana Cocco; Domenico De Rasmo
Journal:  Int J Mol Sci       Date:  2022-08-25       Impact factor: 6.208

5.  Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.

Authors:  Simon C Johnson; Melana E Yanos; Alessandro Bitto; Anthony Castanza; Arni Gagnidze; Brenda Gonzalez; Kanav Gupta; Jessica Hui; Conner Jarvie; Brittany M Johnson; Nicolas Letexier; Lanny McCanta; Maya Sangesland; Oliver Tamis; Lauren Uhde; Alex Van Den Ende; Peter S Rabinovitch; Yousin Suh; Matt Kaeberlein
Journal:  Front Genet       Date:  2015-07-22       Impact factor: 4.599

6.  Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice.

Authors:  Tim L Emmerzaal; Graeme Preston; Bram Geenen; Vivienne Verweij; Maximilian Wiesmann; Elisavet Vasileiou; Femke Grüter; Corné de Groot; Jeroen Schoorl; Renske de Veer; Monica Roelofs; Martijn Arts; Yara Hendriksen; Eva Klimars; Taraka R Donti; Brett H Graham; Eva Morava; Richard J Rodenburg; Tamas Kozicz
Journal:  Transl Psychiatry       Date:  2020-06-01       Impact factor: 6.222
  6 in total

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