Literature DB >> 16116948

Effects of oxidized low density lipoprotein on the expression and function of ABCA1 in macrophages.

Yinghong Li1, Hao Bi, Fan Wu, Yiqiang Zong, Yan Wang, Shen Qu.   

Abstract

In the present study, we examined the regulation of the expression and function of ABCA1 by modified LDL (ox-LDL) in vitro. After incubation with apoA-I for 24 h, RAW264.7 cells effluxed 37.65% cholesterol loaded by acetyl LDL (ac-LDL), and 9.78% cholesterol in ox-LDL group. The level of ABCA1 mRNA increased about three times either when cells were incubated with -100 microg /mL ac-LDL or with 100 microg /mL ox-LDL. However, the level of ABCA1 protein rose by 1.57 times in ac-LDL group and 1.26 times in ox-LDL group. These results demonstrated that ox-LDL had different effect on the expression and function of ABCA1, ox-LDL might decrease the cholesterol efflux mediated by ABCA1 through other unknown mechanisms.

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Year:  2005        PMID： 16116948     DOI： 10.1007/BF02873552

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  15 in total

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Journal:  J Lipid Res       Date:  2001-08       Impact factor: 5.922

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Journal:  Nat Genet       Date:  2000-02       Impact factor: 38.330

Review 4.  Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.

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Journal:  N Engl J Med       Date:  1989-04-06       Impact factor: 91.245

5.  Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

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Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

6.  Decreased cellular cholesterol efflux is a common cause of familial hypoalphalipoproteinemia: role of the ABCA1 gene mutations.

Authors:  S Mott; L Yu; M Marcil; B Boucher; C Rondeau; J Genest
Journal:  Atherosclerosis       Date:  2000-10       Impact factor: 5.162

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Journal:  J Tongji Med Univ       Date:  1995

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Journal:  Nature       Date:  1997-03-20       Impact factor: 49.962

9.  Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally.

Authors:  B S Dhaliwal; U P Steinbrecher
Journal:  J Lipid Res       Date:  2000-10       Impact factor: 5.922

10.  Apolipoprotein A-I-mediated efflux of sterols from oxidized LDL-loaded macrophages.

Authors:  L Kritharides; W Jessup; E L Mander; R T Dean
Journal:  Arterioscler Thromb Vasc Biol       Date:  1995-02       Impact factor: 8.311
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