Literature DB >> 16116138

Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND.

K A Josephs1, D S Knopman, J L Whitwell, B F Boeve, J E Parisi, R C Petersen, D W Dickson.   

Abstract

Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

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Year:  2005        PMID： 16116138     DOI： 10.1212/01.wnl.0000173178.67986.7f

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  30 in total

1.  Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy.

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Authors:  F Geser; D Prvulovic; L O'Dwyer; O Hardiman; P Bede; A L W Bokde; J Q Trojanowski; H Hampel
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4.  Parkinsonism and frontotemporal dementia: the clinical overlap.

Authors:  Alberto J Espay; Irene Litvan
Journal:  J Mol Neurosci       Date:  2011-09-03       Impact factor: 3.444

5.  Biomarkers in the primary progressive aphasias.

Authors:  Murray Grossman
Journal:  Aphasiology       Date:  2014-09       Impact factor: 2.773

6.  Right temporal variant frontotemporal dementia with motor neuron disease.

Authors:  Elizabeth A Coon; Jennifer L Whitwell; Joseph E Parisi; Dennis W Dickson; Keith A Josephs
Journal:  J Clin Neurosci       Date:  2011-11-02       Impact factor: 1.961

7.  Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis.

Authors:  Richard A Armstrong; William Ellis; Ronald L Hamilton; Ian R A Mackenzie; John Hedreen; Marla Gearing; Thomas Montine; Jean-Paul Vonsattel; Elizabeth Head; Andrew P Lieberman; Nigel J Cairns
Journal:  J Neural Transm (Vienna)       Date:  2009-12-10       Impact factor: 3.575

8.  Survival profiles of patients with frontotemporal dementia and motor neuron disease.

Authors:  William T Hu; Harro Seelaar; Keith A Josephs; David S Knopman; Bradley F Boeve; Eric J Sorenson; Leo McCluskey; Lauren Elman; Helenius J Schelhaas; Joseph E Parisi; Benno Kuesters; Virginia M-Y Lee; John Q Trojanowski; Ronald C Petersen; John C van Swieten; Murray Grossman
Journal:  Arch Neurol       Date:  2009-11

9.  Rapidly progressive neurodegenerative dementias.

Authors:  Keith A Josephs; J Eric Ahlskog; Joseph E Parisi; Bradley F Boeve; Brian A Crum; Caterina Giannini; Ronald C Petersen
Journal:  Arch Neurol       Date:  2009-02

10.  Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia.

Authors:  David J Irwin; Corey T McMillan; EunRan Suh; John Powers; Katya Rascovsky; Elisabeth M Wood; Jon B Toledo; Steven E Arnold; Virginia M-Y Lee; Vivianna M Van Deerlin; John Q Trojanowski; Murray Grossman
Journal:  Neurology       Date:  2014-07-03       Impact factor: 9.910
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