Literature DB >> 16116137

Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers.

R O'Hara1, C M Schröder, H C Kraemer, N Kryla, C Cao, E Miller, A F Schatzberg, J A Yesavage, G M Murphy.   

Abstract

The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.

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Year:  2005        PMID： 16116137     DOI： 10.1212/01.wnl.0000173055.75950.bf

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  41 in total

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Review 7.  Sleep, Cognition and Dementia.

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8.  APOE Genotype and Nonrespiratory Sleep Parameters in Cognitively Intact Older Adults.

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9.  Interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals.

Authors:  Ricardo S Osorio; Indu Ayappa; Janna Mantua; Tyler Gumb; Andrew Varga; Anne M Mooney; Omar E Burschtin; Zachary Taxin; Emmanuel During; Nicole Spector; Milton Biagioni; Elizabeth Pirraglia; Hiuyan Lau; Henrik Zetterberg; Kaj Blennow; Shou-En Lu; Lisa Mosconi; Lidia Glodzik; David M Rapoport; Mony J de Leon
Journal:  Neurobiol Aging       Date:  2013-12-27       Impact factor: 4.673

10.  Alzheimer's disease, sleep apnea, and positive pressure therapy.

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Journal:  Curr Treat Options Neurol       Date:  2013-12       Impact factor: 3.598
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