| Literature DB >> 16115769 |
Bandarpalle B Shankar1, Brian J Lavey, Guowei Zhou, James A Spitler, Ling Tong, Razia Rizvi, De-Yi Yang, Ronald Wolin, Joseph A Kozlowski, Neng-Yang Shih, Jie Wu, R William Hipkin, Waldemar Gonsiorek, Charles A Lunn.
Abstract
We recently reported that compound 1 is a potent inhibitor of the CB2 receptor with high selectivity over CB1. This paper describes the SAR development for this class of compounds. Variation of the substitution pattern on the aromatic rings, as well as the groups linking them together, led to sub-nanomolar inhibitors of the CB2 receptor, with high selectivity over CB1.Entities:
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Year: 2005 PMID： 16115769 DOI： 10.1016/j.bmcl.2005.07.023
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823