Literature DB >> 16115768

New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors.

Bernard Hulin1, Shawn Cabral, Michael G Lopaze, Maria A Van Volkenburg, Kim M Andrews, Janice C Parker.   

Abstract

Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity.

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Year:  2005        PMID： 16115768     DOI： 10.1016/j.bmcl.2005.07.026

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  3D-QSAR studies of Dipeptidyl peptidase IV inhibitors using a docking based alignment.

Authors:  Raghuvir R S Pissurlenkar; Mushtaque S Shaikh; Evans C Coutinho
Journal:  J Mol Model       Date:  2007-08-04       Impact factor: 1.810

2.  Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.

Authors:  Donald A Patrick; J Robert Gillespie; Joshua McQueen; Matthew A Hulverson; Ranae M Ranade; Sharon A Creason; Zackary M Herbst; Michael H Gelb; Frederick S Buckner; Richard R Tidwell
Journal:  J Med Chem       Date:  2016-12-19       Impact factor: 7.446

3.  2-(3,3,4,4-Tetra-fluoro-pyrrolidin-1-yl)aniline.

Authors:  Wanwan Cao; Jun-Wen Zhong; Jin Wang; Pei-Lian Liu; Zhuo Zeng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-08-02

4.  The vicinal difluoro motif: The synthesis and conformation of erythro- and threo- diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives.

Authors:  David O'Hagan; Henry S Rzepa; Martin Schüler; Alexandra M Z Slawin
Journal:  Beilstein J Org Chem       Date:  2006-10-02       Impact factor: 2.883
  4 in total

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