Literature DB >> 16115762

Synthesis and evaluation of anti-HIV activity of isatin beta-thiosemicarbazone derivatives.

Tanushree Ratan Bal1, Balasubramani Anand, Perumal Yogeeswari, Dharmarajan Sriram.   

Abstract

On the basis of pharmacophoric modelling studies of existing NNRTIs, a series of isatin beta-thiosemicarbazone derivatives was synthesized and evaluated for their anti-HIV activity in HTLV-III(B) strain in the CEM cell line. Three compounds showed significant anti-HIV activity, whereupon compound 6 was found to be the most active compound with an EC(50) value of 2.62 microM and a selectivity index of 17.41, while not being cytotoxic to the cell line at a CC(50) value of 44.90 microM. Other tested compounds exhibited marked activity below their toxicity threshold.

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Year:  2005        PMID： 16115762     DOI： 10.1016/j.bmcl.2005.07.046

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  30 in total

1.  Inhibition of bovine viral diarrhea virus RNA synthesis by thiosemicarbazone derived from 5,6-dimethoxy-1-indanone.

Authors:  Eliana F Castro; Lucas E Fabian; María E Caputto; Dolores Gagey; Liliana M Finkielsztein; Graciela Y Moltrasio; Albertina G Moglioni; Rodolfo H Campos; Lucía V Cavallaro
Journal:  J Virol       Date:  2011-03-23       Impact factor: 5.103

2.  Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells.

Authors:  Belkis Atasever; Bahri Ulküseven; Tülay Bal-Demirci; Serap Erdem-Kuruca; Zeynep Solakoğlu
Journal:  Invest New Drugs       Date:  2009-06-04       Impact factor: 3.850

3.  Molecular docking of (5E)-3-(2-aminoethyl)-5-(2- thienylmethylene)-1, 3-thiazolidine-2, 4-dione on HIV-1 reverse transcriptase: novel drug acting on enzyme.

Authors:  Chandrabhan Seniya; Ajay Yadav; Kuldeep Uchadia; Sanjay Kumar; Nitin Sagar; Priyanka Shrivastava; Shilpi Shrivastava; Gulshan Wadhwa
Journal:  Bioinformation       Date:  2012-07-21

4.  Nano-ZnO catalyzed multicomponent one-pot synthesis of novel spiro(indoline-pyranodioxine) derivatives.

Authors:  Harshita Sachdeva; Rekha Saroj; Diksha Dwivedi
Journal:  ScientificWorldJournal       Date:  2014-02-05

5.  Study on the Interaction between Isatin-β-Thiosemicarbazone and Calf Thymus DNA by Spectroscopic Techniques.

Authors:  Parvaneh Pakravan; Shahla Masoudian
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

6.  Synthesis and characterization of new Schiff bases derived from N (1)-substituted isatin with dithiooxamide and their Co(II), Ni(II), Cu(II), Pd(II), and Pt(IV) complexes.

Authors:  Ahlam J Abdul-Ghani; Asmaa M N Khaleel
Journal:  Bioinorg Chem Appl       Date:  2009-10-26       Impact factor: 7.778

7.  An Efficient Synthesis, Spectroscopic Characterization, and Optical Nonlinearity Response of Novel Salicylaldehyde Thiosemicarbazone Derivatives.

Authors:  Muhammad Khalid; Rifat Jawaria; Muhammad Usman Khan; Ataualpa Albert Carmo Braga; Zahid Shafiq; Muhammad Imran; Hafiz Muhammad Ahmad Zafar; Ahmad Irfan
Journal:  ACS Omega       Date:  2021-06-11

8.  TFA-catalyzed Q-Tube Reactor-Assisted Strategy for the Synthesis of Pyrido[1,2-b][1,2,4]triazine and Pyrido[1',2':2,3][1,2,4]triazino[5,6-b]indole Derivatives.

Authors:  Hamada Mohamed Ibrahim; Haider Behbehani
Journal:  ACS Omega       Date:  2021-06-08

9.  Antimicrobial activity of a series of thiosemicarbazones and their Zn(II) and Pd(II) complexes.

Authors:  I Kizilcikli; Y D Kurt; B Akkurt; A Y Genel; S Birteksöz; G Otük; B Ulküseven
Journal:  Folia Microbiol (Praha)       Date:  2007       Impact factor: 2.629

10.  N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo.

Authors:  Liba Sebastian; Anita Desai; Madhusudana N Shampur; Yogeeswari Perumal; D Sriram; Ravi Vasanthapuram
Journal:  Virol J       Date:  2008-05-22       Impact factor: 4.099
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