Literature DB >> 16113344

Mannheimia (Pasteurella) haemolytica leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18.

R S Gopinath1, T C Ambagala, M S Deshpande, R O Donis, S Srikumaran.   

Abstract

Previously, we identified bovine CD18 as the receptor for leukotoxin secreted by Mannheimia (Pasteurella) haemolytica. In this study, we constructed bovine-murine CD18 chimeras to locate the leukotoxin binding domain on CD18. Leukotoxin specifically lysed transfectants expressing bovine CD18 fragment encompassing amino acids 1 to 291, indicating that leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18.

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Year:  2005        PMID： 16113344      PMCID： PMC1231049          DOI： 10.1128/IAI.73.9.6179-6182.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  13 in total

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Authors:  T C Ambagala; A P Ambagala; S Srikumaran
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2.  Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain.

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Review 3.  The leukocyte integrins.

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Journal:  J Biol Chem       Date:  2000-08-04       Impact factor: 5.157

4.  Sequence of the bovine CD18-encoding cDNA: comparison with the human and murine glycoproteins.

Authors:  D E Shuster; B T Bosworth; M E Kehrli
Journal:  Gene       Date:  1992-05-15       Impact factor: 3.688

5.  Nucleotide sequence of the cDNA from the mouse leukocyte adhesion protein CD18.

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Journal:  Nucleic Acids Res       Date:  1989-07-11       Impact factor: 16.971

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7.  Lymphocyte function-associated antigen 1 is a receptor for Pasteurella haemolytica leukotoxin in bovine leukocytes.

Authors:  S Jeyaseelan; S L Hsuan; M S Kannan; B Walcheck; J F Wang; M E Kehrli; E T Lally; G C Sieck; S K Maheswaran
Journal:  Infect Immun       Date:  2000-01       Impact factor: 3.441

8.  Neutralizing monoclonal antibodies to Pasteurella haemolytica leukotoxin affinity-purify the toxin from crude culture supernatants.

Authors:  M J Gentry; S Srikumaran
Journal:  Microb Pathog       Date:  1991-05       Impact factor: 3.738

9.  Cytotoxic effects of Pasteurella haemolytica on bovine neutrophils.

Authors:  K A Berggren; C S Baluyut; R R Simonson; W J Bemrick; S K Maheswaran
Journal:  Am J Vet Res       Date:  1981-08       Impact factor: 1.156

10.  Bovine CD18 is necessary and sufficient to mediate Mannheimia (Pasteurella) haemolytica leukotoxin-induced cytolysis.

Authors:  M S Deshpande; T C Ambagala; A P N Ambagala; M E Kehrli; S Srikumaran
Journal:  Infect Immun       Date:  2002-09       Impact factor: 3.441
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  8 in total

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Journal:  Infect Immun       Date:  2007-08-06       Impact factor: 3.441

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Journal:  Infect Immun       Date:  2010-09-07       Impact factor: 3.441

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Authors:  Dhammika N Atapattu; Nicole A Aulik; Darrell R McCaslin; Charles J Czuprynski
Journal:  Microb Pathog       Date:  2009-01-07       Impact factor: 3.738

4.  Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.

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Journal:  FEMS Microbiol Rev       Date:  2010-11       Impact factor: 16.408

7.  Porcine CD18 mediates Actinobacillus pleuropneumoniae ApxIII species-specific toxicity.

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Journal:  Vet Res       Date:  2009-04-10       Impact factor: 3.683

Review 8.  RTX Toxins Ambush Immunity's First Cellular Responders.

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Journal:  Toxins (Basel)       Date:  2019-12-10       Impact factor: 4.546
  8 in total

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