Literature DB >> 16113178

Simplifying thrombolysis decisions in patients with left bundle branch block.

A D Reuben1, C J Mann.   

Abstract

OBJECTIVES: To redesign and simplify an existing decision algorithm for the management of patients who present to the emergency department with chest pain and left bundle branch block (LBBB) based on the Sgarbossa criteria. To compare its reliability with the current algorithm.
METHODS: A simplified algorithm was created and tested against the existing algorithm. Electrocardiograms (ECGs) of patients with LBBB were presented to 10 emergency department doctors with both old and new algorithms a week apart. Six ECGs displayed the relevant criteria for thrombolysis and had proven acute myocardial infarction (AMI) based on a gold standard of enzyme measurements. Subjects were asked whether or not they would thrombolyse a patient presenting with the given ECG using each of the algorithms as a guide.
RESULTS: The new algorithm has demonstrated improvements in terms of an increase in appropriate thrombolysis and a reduction in inappropriate thrombolysis. Specificity for AMI rose from 0.85 to 0.99 and sensitivity from 0.38 to 0.6. kappa score showed greater agreement with the gold standard.
CONCLUSION: Patients with AMI and LBBB have a significantly poorer outcome than those without LBBB. Despite this, thrombolysis is less likely to be given to patients with AMI and LBBB. This study demonstrates that in part this is because of cognitive difficulties using the current algorithm. The proposed proforma addresses these issues and provides a simple tool to aid appropriate treatment in this group of patients.

Entities:  

Mesh:

Year:  2005        PMID: 16113178      PMCID: PMC1726923          DOI: 10.1136/emj.2003.013987

Source DB:  PubMed          Journal:  Emerg Med J        ISSN: 1472-0205            Impact factor:   2.740


  17 in total

Review 1.  Which patients with suspected myocardial ischemia and left bundle-branch block should receive thrombolytic agents?

Authors:  E J Gallagher
Journal:  Ann Emerg Med       Date:  2001-05       Impact factor: 5.721

2.  Electrocardiographic diagnosis of myocardial infarction in patients with left bundle branch block.

Authors:  S F Li; P L Walden; O Marcilla; E J Gallagher
Journal:  Ann Emerg Med       Date:  2000-12       Impact factor: 5.721

3.  Can myocardial infarction be rapidly identified in emergency department patients who have left bundle-branch block?

Authors:  M C Kontos; R H McQueen; R L Jesse; J L Tatum; J P Ornato
Journal:  Ann Emerg Med       Date:  2001-05       Impact factor: 5.721

4.  Suspected myocardial infarction and left bundle branch block: electrocardiographic indicators of acute ischaemia.

Authors:  J A Edhouse; M Sakr; J Angus; F P Morris
Journal:  J Accid Emerg Med       Date:  1999-09

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Journal:  Cardiovasc Clin       Date:  1974

6.  A critique of the new ST-segment criteria for the diagnosis of acute myocardial infarction in patients with left bundle-branch block.

Authors:  J E Madias; A Sinha; R Ashtiani; H Agarwal; M Win; V K Narayan
Journal:  Clin Cardiol       Date:  2001-10       Impact factor: 2.882

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Journal:  Int J Cardiol       Date:  1983       Impact factor: 4.164

8.  Should the electrocardiogram be used to guide therapy for patients with left bundle-branch block and suspected myocardial infarction?

Authors:  M G Shlipak; W L Lyons; A S Go; T M Chou; G T Evans; W S Browner
Journal:  JAMA       Date:  1999-02-24       Impact factor: 56.272

9.  Use of reperfusion therapy for acute myocardial infarction in the United States: data from the National Registry of Myocardial Infarction 2.

Authors:  H V Barron; L J Bowlby; T Breen; W J Rogers; J G Canto; Y Zhang; A J Tiefenbrunn; W D Weaver
Journal:  Circulation       Date:  1998-03-31       Impact factor: 29.690

10.  The clinical significance of bundle branch block complicating acute myocardial infarction. 1. Clinical characteristics, hospital mortality, and one-year follow-up.

Authors:  M C Hindman; G S Wagner; M JaRo; J M Atkins; M M Scheinman; R W DeSanctis; A H Hutter; L Yeatman; M Rubenfire; C Pujura; M Rubin; J J Morris
Journal:  Circulation       Date:  1978-10       Impact factor: 29.690

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  2 in total

1.  Simpler thrombolysis decisions in patients with left bundle branch block.

Authors:  J R Benger
Journal:  Emerg Med J       Date:  2006-04       Impact factor: 2.740

2.  To perform thrombolysis or not: a case of acute pancreatitis presenting with chest pain and transient left bundle branch block.

Authors:  S Ullah; S Mehmood; H A Chatha; A Mahmood
Journal:  Case Rep Med       Date:  2010-09-14
  2 in total

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