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Literature DB >> 16112864

Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.

Guangrong Zheng¹, Linda P Dwoskin, Agripina G Deaciuc, Peter A Crooks.

Abstract

A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at alpha4beta2* and alpha7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2.

Entities: Chemical Gene

Mesh：

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Year: 2005 PMID： 16112864 PMCID： PMC3602420 DOI： 10.1016/j.bmcl.2005.07.032

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

22 in total

Review 1. Brain reward circuitry: insights from unsensed incentives.

Authors: Roy A Wise
Journal: Neuron Date: 2002-10-10 Impact factor: 17.173

2. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

Authors: N Takahashi; L L Miner; I Sora; H Ujike; R S Revay; V Kostic; V Jackson-Lewis; S Przedborski; G R Uhl
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

Review 3. The role of vesicular transport proteins in synaptic transmission and neural degeneration.

Authors: Y Liu; R H Edwards
Journal: Annu Rev Neurosci Date: 1997 Impact factor: 12.449

Review 4. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse.

Authors: Linda P Dwoskin; Peter A Crooks
Journal: Biochem Pharmacol Date: 2002-01-15 Impact factor: 5.858

5. Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine.

Authors: Y M Wang; R R Gainetdinov; F Fumagalli; F Xu; S R Jones; C B Bock; G W Miller; R M Wightman; M G Caron
Journal: Neuron Date: 1997-12 Impact factor: 17.173

6. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter.

Authors: C Pifl; H Drobny; H Reither; O Hornykiewicz; E A Singer
Journal: Mol Pharmacol Date: 1995-02 Impact factor: 4.436

Review 7. The Interactions of the 5-HT(3) receptor with arylpiperazine, tropane, and quinuclidine ligands.

Authors: Andrea Cappelli; Maurizio Anzini; Salvatore Vomero; Laura Mennuni; Francesco Makovec; Michel Hamon; Pier G De Benedetti; M Cristina Menziani
Journal: Curr Top Med Chem Date: 2002-06 Impact factor: 3.295

8. Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.

Authors: Dennis K Miller; Peter A Crooks; Guangrong Zheng; Vladimir P Grinevich; Seth D Norrholm; Linda P Dwoskin
Journal: J Pharmacol Exp Ther Date: 2004-04-30 Impact factor: 4.030

9. In vitro and in vivo studies of benzisoquinoline ligands for the brain synaptic vesicle monoamine transporter.

Authors: L C Lee; T Vander Borght; P S Sherman; K A Frey; M R Kilbourn
Journal: J Med Chem Date: 1996-01-05 Impact factor: 7.446

Review 10. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole.

Authors: Amy Hauck Newman; Santosh Kulkarni
Journal: Med Res Rev Date: 2002-09 Impact factor: 12.944

9 in total

1. Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.

Authors: Fang Zheng; Guangrong Zheng; A Gabriela Deaciuc; Chang-Guo Zhan; Linda P Dwoskin; Peter A Crooks
Journal: Bioorg Med Chem Date: 2007-02-11 Impact factor: 3.641

Review 2. Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.

Authors: Peter A Crooks; Guangrong Zheng; Ashish P Vartak; John P Culver; Fang Zheng; David B Horton; Linda P Dwoskin
Journal: Curr Top Med Chem Date: 2011 Impact factor: 3.295

3. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.

Authors: Shyamsunder R Joolakanti; Justin R Nickell; Venumadhav Janganati; Guangrong Zheng; Linda P Dwoskin; Peter A Crooks
Journal: Bioorg Med Chem Lett Date: 2016-04-01 Impact factor: 2.823

4. Synthesis of Lobeline, Lobelane and their Analogues. A Review.

Authors: Guangrong Zheng; Peter A Crooks
Journal: Org Prep Proced Int Date: 2015-08-17 Impact factor: 1.628

Review 5. Vesicular monoamine transporter 2: role as a novel target for drug development.

Authors: Guangrong Zheng; Linda P Dwoskin; Peter A Crooks
Journal: AAPS J Date: 2006-11-10 Impact factor: 4.009

6. Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.

Authors: Guangrong Zheng; David B Horton; Narsimha Reddy Penthala; Justin R Nickell; John P Culver; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Journal: Medchemcomm Date: 2013-03 Impact factor: 3.597