| Literature DB >> 16112862 |
S Bogen1, A K Saksena, A Arasappan, H Gu, F G Njoroge, V Girijavallabhan, J Pichardo, N Butkiewicz, A Prongay, V Madison.
Abstract
Modification of the P(2) and P(1) side chains of earlier P(3)-capped alpha-ketoamide inhibitor of HCV NS3 serine protease 1 resulted in the discovery of compound 24 with about 10-fold improvement in potency.Entities:
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Year: 2005 PMID： 16112862 DOI： 10.1016/j.bmcl.2005.07.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823