Literature DB >> 16112688

Mathematical modeling of the hypothalamic-pituitary-adrenal system activity.

Smiljana Jelić1, Zeljko Cupić, Ljiljana Kolar-Anić.   

Abstract

Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet.

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Year:  2005        PMID： 16112688     DOI： 10.1016/j.mbs.2005.06.006

Source DB:  PubMed          Journal:  Math Biosci        ISSN： 0025-5564            Impact factor:   2.144


  13 in total

1.  Transcriptional implications of ultradian glucocorticoid secretion in homeostasis and in the acute stress response.

Authors:  Jeremy D Scheff; Steve E Calvano; Stephen F Lowry; Ioannis P Androulakis
Journal:  Physiol Genomics       Date:  2011-11-29       Impact factor: 3.107

Review 2.  Modeling the hypothalamus-pituitary-adrenal axis: A review and extension.

Authors:  Niyousha Hosseinichimeh; Hazhir Rahmandad; Andrea K Wittenborn
Journal:  Math Biosci       Date:  2015-08-12       Impact factor: 2.144

3.  Modeling the hypothalamus-pituitary-adrenal system: homeostasis by interacting positive and negative feedback.

Authors:  Matthias Conrad; Christian Hubold; Bernd Fischer; Achim Peters
Journal:  J Biol Phys       Date:  2009-02-25       Impact factor: 1.365

4.  The minimal model of the hypothalamic-pituitary-adrenal axis.

Authors:  Frank Vinther; Morten Andersen; Johnny T Ottesen
Journal:  J Math Biol       Date:  2010-11-24       Impact factor: 2.259

5.  Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and post-traumatic stress disorder (PTSD) in humans.

Authors:  K Sriram; Maria Rodriguez-Fernandez; Francis J Doyle
Journal:  PLoS Comput Biol       Date:  2012-02-16       Impact factor: 4.475

6.  Differentiation between genomic and non-genomic feedback controls yields an HPA axis model featuring hypercortisolism as an irreversible bistable switch.

Authors:  Clemens A Zarzer; Martin G Puchinger; Gottfried Köhler; Philipp Kügler
Journal:  Theor Biol Med Model       Date:  2013-11-09       Impact factor: 2.432

7.  Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics.

Authors:  Lae U Kim; Maria R D'Orsogna; Tom Chou
Journal:  Biol Direct       Date:  2016-03-25       Impact factor: 4.540

Review 8.  Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on Health.

Authors:  Nicolas C Nicolaides; Evangelia Charmandari; Tomoshige Kino; George P Chrousos
Journal:  Front Endocrinol (Lausanne)       Date:  2017-04-28       Impact factor: 5.555

9.  Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling.

Authors:  Osama A Abulseoud; Man Choi Ho; Doo-Sup Choi; Ana Stanojević; Željko Čupić; Ljiljana Kolar-Anić; Vladana Vukojević
Journal:  PLoS One       Date:  2017-05-18       Impact factor: 3.240

10.  A mathematical model of aging-related and cortisol induced hippocampal dysfunction.

Authors:  Mark T McAuley; Rose Anne Kenny; Thomas B L Kirkwood; Darren J Wilkinson; Janette J L Jones; Veronica M Miller
Journal:  BMC Neurosci       Date:  2009-03-25       Impact factor: 3.288
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