Literature DB >> 16112634

Interleukin-6: An osteotropic factor influencing bone formation?

Nathalie Franchimont1, Sylvie Wertz, Michel Malaise.   

Abstract

Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper, the effects of IL-6 and its soluble receptor on osteoblast proliferation, differentiation and apoptosis are readdressed. A brief summary of IL-6 signaling after binding to its receptor is provided and hypotheses concerning IL-6 and the central control of bone formation are also highlighted.

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Year:  2005        PMID： 16112634     DOI： 10.1016/j.bone.2005.06.002

Source DB:  PubMed          Journal:  Bone        ISSN： 1873-2763            Impact factor:   4.398


  45 in total

1.  Suppressor of cytokine signaling 3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein {beta} activity.

Authors:  Chunguang Yan; Jay Cao; Min Wu; Wei Zhang; Tao Jiang; Aihiko Yoshimura; Hongwei Gao
Journal:  J Biol Chem       Date:  2010-09-28       Impact factor: 5.157

2.  The skeletal muscle secretome: an emerging player in muscle-bone crosstalk.

Authors:  Mark W Hamrick
Journal:  Bonekey Rep       Date:  2012-04-11

Review 3.  The bone-adipose axis in obesity and weight loss.

Authors:  J Gómez-Ambrosi; A Rodríguez; V Catalán; G Frühbeck
Journal:  Obes Surg       Date:  2008-06-19       Impact factor: 4.129

4.  The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation.

Authors:  C Collet; C Schiltz; V Geoffroy; L Maroteaux; J-M Launay; M-C de Vernejoul
Journal:  FASEB J       Date:  2007-09-10       Impact factor: 5.191

5.  IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro.

Authors:  Shoichi Kaneshiro; Kosuke Ebina; Kenrin Shi; Chikahisa Higuchi; Makoto Hirao; Michio Okamoto; Kota Koizumi; Tokimitsu Morimoto; Hideki Yoshikawa; Jun Hashimoto
Journal:  J Bone Miner Metab       Date:  2014-07       Impact factor: 2.626

6.  TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells.

Authors:  Graeme E Glass; James K Chan; Andrew Freidin; Marc Feldmann; Nicole J Horwood; Jagdeep Nanchahal
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-05       Impact factor: 11.205

7.  Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation.

Authors:  Gregory A Clines; Khalid S Mohammad; Yongde Bao; Owen W Stephens; Larry J Suva; John D Shaughnessy; Jay W Fox; John M Chirgwin; Theresa A Guise
Journal:  Mol Endocrinol       Date:  2006-10-26

8.  Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.

Authors:  Jumpei Teramachi; Hua Zhou; Mark A Subler; Yukiko Kitagawa; Deborah L Galson; David W Dempster; Jolene J Windle; Noriyoshi Kurihara; G David Roodman
Journal:  J Bone Miner Res       Date:  2014-06       Impact factor: 6.741

9.  Depression induces bone loss through stimulation of the sympathetic nervous system.

Authors:  Raz Yirmiya; Inbal Goshen; Alon Bajayo; Tirzah Kreisel; Sharon Feldman; Joseph Tam; Victoria Trembovler; Valér Csernus; Esther Shohami; Itai Bab
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-30       Impact factor: 11.205

Review 10.  Mechanisms of growth impairment in pediatric Crohn's disease.

Authors:  Thomas D Walters; Anne M Griffiths
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2009-09       Impact factor: 46.802
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